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. 2010 Sep 1;59(11):2936–2940. doi: 10.2337/db10-0728

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© 2010 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — Mean ± SE plasma insulin and glucose concentrations and change (Δ) in plasma glucagon concentrations in patients with type 1 diabetes during infusions of zinc-free insulin glulisine with clamped euglycemia from 0 to 60 min on three occasions (decrements in plasma glucagon all P < 0.01) and following 1) discontinuation of insulin glulisine with clamped euglycemia (○), 2) discontinuation of insulin glulisine with clamped hypoglycemia (●) (increments in plasma glucagon P < 0.01), and 3) continuation of insulin glulisine with clamped hypoglycemia (▴), each from 60 to 180 min. Arg, arginine.