FIG. 7.
Effects of compound C, H-89, and antioxidants on adiponectin-mediated suppression of p38 MAPK phosphorylation, p16INK4A expression, and cellular senescence in human EPCs. Cells were grown in normal (open bar) or high (black bar) glucose and were treated with or without 15 μg/ml adiponectin (ADN), 5 μmol/l compound C (CC), 5 μmol/l H-89, or 2 mmol/l of the antioxidant NAC as indicated. *P < 0.05, **P < 0.01 vs. the high-glucose plus adiponectin group. ##P < 0.01 vs. the high-glucose group. n = 4–6.