TABLE 3.

HLA class I alleles significantly different from expected values when accounting for LD with DRB1-DQB1

Allele	Type 1 diabetes observed (%)	Type 1 diabetes expected (%)†	OR (95% CI)	P
A*0101	17.7	21.9	0.77 (0.66–0.88)	0.002
A*0201	30.6	24.7	1.35 (1.17–1.54)	3.E-04
A*1101	3.4	6.2	0.53 (0.40–0.70)	8.E-06
A*2402	11.4	7.0	1.71 (1.37–2.12)	5.E-06
A*3201	2.1	3.8	0.54 (0.37–0.75)	4.E-04
A*6601	0.1	0.6	0.16 (0.04–0.57)	9.E-04
A*6802	0.4	1.2	0.34 (0.17–0.69)	0.002
B*0702	7.0	11.4	0.58 (0.47–0.70)	3.E-07
B*0705	0.7	0.2	3.42 (1.11–10.5)	0.023
B*1501	12.3	9.4	1.36 (1.11–1.65)	0.004
B*1801	10.2	5.2	2.05 (1.59–2.61)	3.E-08
B*3501	3.6	4.9	0.72 (0.53–0.96)	0.028
B*3502	0.3	1.2	0.29 (0.14–0.60)	5.E-04
B*3906	3.2	0.3	10.31 (4.21–25.1)	4.E-10
B*4002	0.5	1.2	0.45 (0.23–0.84)	0.012
B*4101	1.0	0.2	4.49 (1.48–13.6)	0.004
B*4102	0.1	0.3	0.19 (0.03–0.96)	0.020
B*4403	1.9	4.5	0.42 (0.30–0.59)	4.E-07
B*4901	2.2	0.9	2.6 (1.45–4.63)	0.001
B*5001	2.1	1.0	2.27 (1.30–3.94)	0.003
B*5201	0.3	0.9	0.37 (0.17–0.80)	0.009
B*5301	0.1	0.4	0.33 (0.10–1.06)	0.055
B*5701	0.5	2.8	0.19 (0.11–0.32)	4.E-11
B*5703	0.0	0.3	0.11 (0.01–0.96)	0.013
C*0303	5.5	3.8	1.48 (1.10–1.99)	0.010
C*0401	6.0	9.3	0.63 (0.50–0.78)	6.E-05
C*0501	11.3	7.6	1.56 (1.26–1.93)	9.E-05
C*1202	0.3	0.9	0.39 (0.17–0.83)	0.014
C*1402	0.7	1.4	0.52 (0.29–0.93)	0.027
C*1505	0.8	0.3	2.78 (1.01–7.62)	0.039
C*1601	1.2	3.0	0.39 (0.25–0.58)	5.E-06

†Expected values calculated based on LD of class I alleles with DR-DQ–encoding loci in this population.