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. Author manuscript; available in PMC: 2010 Oct 25.
Published in final edited form as: Trends Endocrinol Metab. 2008 May 27;19(6):223–230. doi: 10.1016/j.tem.2008.04.001

Figure 1.

Figure 1

Domain composition and phylogeny of PHLPP isoforms

A. Domain composition of PHLPP family members showing the Ras association domain (RA; dark blue), pleckstrin homology domain (PH; cyan), Leucine rich repeat (LRR; orange) region, PP2C domain (yellow), and PDZ binding motif (pink). Gray arrow head denotes the splice site for PHLPP1β. B. Phylogenetic tree of PPM phosphatase domains (human) showing PHLPP as a discrete subfamily (highlighted in yellow) of the PP2C class. Sequences were aligned using ClustalW (Gonnet matrix)