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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Exp Hematol. 2010 Jul 18;38(11):1036–1046.e4. doi: 10.1016/j.exphem.2010.07.004

Figure 3.

Figure 3

Alox15 GMP exhibit defective differentiation. B6 and Alox15 BM were isolated and sorted for myeloid progenitors. LSK (A), CMP (B) and GMP (C) were plated in methylcellulose in the presence of IL-3, IL-6, SCF and Epo. Shown are a summary of three experiments as colonies enumerated and the CFU-G/CFU-M ratio. (D) B6 and Alox15 GMP were plated in the presence of M-CSF or G-CSF in methylcellulose assays. n=6 in three independent experiments for all data shown*p<.05, **p<.01 Error bars represent ± SEM. (E) Diagram of GMP differentiation in Alox15 mice. There is an accumulation of Alox15 GMP which exhibit reduced monocyte differentiation and enhanced granulopoiesis.