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. 2010 Oct 25;5(10):e13600. doi: 10.1371/journal.pone.0013600

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Love et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A–E) Static compliance (A), airway resistance (B), tissue elastance (C), tissue damping (D) and hysteresivity (E) were measured with positive end-expiratory pressure (PEEP) at 0 cm H₂O in 10- to 13-week-old Cby^−/− (n = 5) and control Cby^+/+ (n = 5) mice. Similar results were obtained at a PEEP of 3 cm H₂O (data not shown). Values were determined by fitting the constant-phase model to measurements of respiratory input impedance (Zrs) from each genotype. All measures were normalized by multiplication by total lung capacity (TLC) except for static compliance that was normalized by division by TLC. Values are means ± SE. Student's t-test; *P<0.05, **P<0.001. (F) Pressure-volume (PV) curve analysis was performed with a PEEP of 0 cm H₂O on adult Cby^−/− (n = 5) and Cby^+/+ (n = 5) littermates. Similar results were obtained at a PEEP of 3 cm H₂O (data not shown). All measures were normalized by division by TLC. Values represent means ± SE. Student'st-test, P<0.05.