Table 3. Genotype and allele frequencies of IL-15 SNPs among ALL cases and controls and associations with risk of ALL.
| SNP | ALL Subjects (Cases/controls) | T-ALL Subjects (Cases/controls) | B-ALL Subjects (Cases/controls) | |||||||
| n (%) | OR (95% CI)* | P | n (%) | OR (95% CI)* | P | n (%) | OR (95% CI)* | P | ||
| rs10519612 | ||||||||||
| Genotype | AA | 38/91 (31.4/34.6) | 1.00 | 10/91 (24.4/34.6) | 1.00 | 28/91 (35.0/34.6) | 1.00 | |||
| AC | 51/135 (42.1/51.3) | 0.88 (0.53–1.45) | 19/135 (46.3/51.3) | 1.25 (0.55–2.84) | 32/135 (40.0/51.3) | 0.74 (0.42–1.32) | ||||
| CC | 32/37 (26.4/14.1) | 1.96 (1.06–3.61)& | 0.013 | 12/37 (29.3/14.1) | 2.68 (1.05–6.83)& | 0.041 | 20/37 (25.0/14.1) | 1.62 (0.81–3.26) | 0.049 | |
| Allele | A | 127/317 (52.5/60.3) | 1.00 | 39/317 (47.6/60.3) | 1.00 | 88/317 (55.0/60.3) | 1.00 | |||
| C | 115/209 (47.5/39.7) | 1.37 (1.01–1.87) | 0.042 | 43/209 (52.4/39.7) | 1.67 (1.05–2.67) | 0.030 | 72/209 (45.0/39.7) | 1.24 (0.87–1.77) | 0.236 | |
| rs10519613 | ||||||||||
| Genotype | CC | 40/103 (33.1/39.2) | 1.00 | 12/103 (29.3/39.2) | 1.00 | 28/103 (35.0/39.2) | 1.00 | |||
| CA | 62/131 (51.2/49.8) | 1.17 (0.73–1.89) | 23/131 (56.1/49.8) | 1.46 (0.69–3.10) | 39/131 (48.7/49.8) | 1.05 (0.60–1.83) | ||||
| AA | 19/29 (15.7/11.0) | 1.56 (0.78–3.11) | 0.315 | 6/29 (14.6/11.0) | 1.48 (0.50–4.40) | 0.450 | 13/29 (16.3/11.0) | 1.49 (0.68–3.28) | 0.436 | |
| Allele | C | 142/337 (58.7/64.1) | 1.00 | 47/337 (57.3/64.1) | 1.00 | 95/337 (59.4/64.1) | 1.00 | |||
| A | 100/189 (41.3/35.9) | 1.26 (0.92–1.72) | 0.152 | 35/189 (42.7/35.9) | 1.33 (0.83–2.13) | 0.238 | 65/189 (40.6/35.9) | 1.22 (0.85–1.75) | 0.282 | |
| rs35964658 | ||||||||||
| Genotype | AA | 31/85 (26.1/32.3) | 1.00 | 10/85 (24.4/32.3) | 1.00 | 21/85 (26.9/32.3) | 1.00 | |||
| AG | 67/142 (56.3/54.0) | 1.25 (0.76–2.08) | 26/142 (63.4/54.0) | 1.48 (0.68–3.25) | 41/142 (52.6/54.0) | 1.12 (0.62–2.02) | ||||
| GG | 21/36 (17.6/13.7) | 1.52 (0.77–3.00) | 0.368 | 5/36 (12.2/13.7) | 1.09 (0.34–3.44) | 0.511 | 16/36 (20.5/13.7) | 1.69 (0.79–3.64) | 0.298 | |
| Allele | A | 129/312 (54.2/59.3) | 1.00 | 46/312 (56.1/59.3) | 1.00 | 83/312 (53.2/59.3) | 1.00 | |||
| G | 109/214 (45.8/40.7) | 1.23 (0.91–1.68) | 0.185 | 36/214 (43.9/40.7) | 1.14 (0.71–1.83) | 0.582 | 73/214 (46.8/40.7) | 1.28 (0.90–1.84) | 0.175 | |
| rs17007695 | ||||||||||
| Genotype | TT | 27/104 (22.3/39.5) | 1.00 | 9/104 (22.0/39.5) | 1.00 | 18/104 (22.5/39.5) | 1.00 | |||
| TC | 80/124 (66.1/47.1) | 2.38 (1.43–3.97)& | 25/124 (61.0/47.1) | 2.28 (1.01–5.17)& | 55/124 (68.8/47.1) | 2.40 (1.32–4.36)& | ||||
| CC | 14/35 (11.6/13.3) | 1.40 (0.65–3.01) | 0.001 | 7/35 (17.1/13.3) | 2.19 (0.74–6.47) | 0.095 | 7/35 (8.7/13.3) | 1.02 (0.39–2.69) | 0.003 | |
| Allele | T | 134/332 (55.4/63.1) | 1.00 | 43/332 (52.4/63.1) | 1.00 | 91/332 (56.9/63.1) | 1.00 | |||
| C | 108/194 (44.6/36.9) | 1.38 (1.01–1.88) | 0.041 | 39/194 (47.6/36.9) | 1.55 (0.97–2.48) | 0.064 | 69/194 (43.1/36.9) | 1.30 (0.91–1.86) | 0.155 | |
| rs17015014 | ||||||||||
| Genotype | GG | 30/75 (24.8/28.5) | 1.00 | 9/75 (22.0/28.5) | 1.00 | 21/75 (26.3/28.5) | 1.00 | |||
| GC | 67/133 (55.4/50.6) | 1.22 (0.73–2.05) | 24/133 (58.5/50.6) | 1.43 (0.63–3.27) | 43/133 (53.7/50.6) | 1.12 (0.62–2.03) | ||||
| CC | 24/55 (19.8/20.9) | 1.07 (0.56–2.03) | 0.659 | 8/55 (19.5/20.9) | 1.20 (0.43–3.36) | 0.600 | 16/55 (20.0/20.9) | 1.03 (0.49–2.17) | 0.879 | |
| Allele | G | 127/283 (52.5/53.8) | 1.00 | 42/283 (51.2/53.8) | 1.00 | 85/283 (53.1/53.8) | 1.00 | |||
| C | 115/243 (47.5/46.2) | 1.06 (0.78–1.43) | 0.733 | 40/243 (48.8/46.2) | 1.11 (0.70–1.77) | 0.663 | 75/243 (46.9/46.2) | 1.03 (0.72–1.47) | 0.880 | |
*Adjusted for age and gender status.
&
P<0.05.
P for Chi-square analysis or Fisher's exact test.