Table 1. Normal reference range established for each individual probe for CLL MLPA.

Probe (gene/chromosome)	Normal range (Mean ± 2SD; 95% CI, P = 0.05)*	Normal range (Mean ± 3SD; 99% CI, P = 0.01)*
PTEN1 10q23.3	0.84–1.16	0.76–1.24
PTEN2 10q23.3	0.89–1.11	0.84–1.16
ATM1 11q23	0.85–1.15	0.78–1.22
ATM2 11q23	0.87–1.13	0.80–1.20
ATM3 11q23	0.84–1.16	0.76–1.24
ATM4 11q23	0.88–1.12	0.82–1.18
RDX 11q23	0.91–1.09	0.86–1.15
CD27 12p13.31	0.82–1.18	0.73–1.27
APAF 12q23.1	0.86–1.14	0.83–1.17
IGF1 12q23	0.87–1.13	0.85–1.15
PAH1 12q23	0.89–1.11	0.83–1.17
PAH2 12q23	0.88–1.12	0.82–1.18
RB1 13q14.2	0.87–1.13	0.81–1.19
KCNRG 13q14.3	0.89–1.11	0.84–1.16
DLEU1 1 13q14.3	0.87–1.13	0.80–1.20
DLEU1 2 13q14.3	0.87–1.13	0.80–1.20
DLEU1 3 13q14.3	0.85–1.15	0.78–1.22
ATP7B 13q14.3	0.87–1.13	0.80–1.20
TP53 1 17p13.1	0.83–1.17	0.74–1.26
TP53 2 17p13.1	0.83–1.17	0.81–1.19
TP53 3 17p13.1	0.83–1.17	0.81–1.19
TP53 4 17p13.1	0.84–1.16	0.76–1.24
SMAD4 18q21.1	0.86–1.14	0.79–1.21
CDKN2D 19p13.2	0.86–1.14	0.80–1.20
LDLR 19p13.2	0.89–1.11	0.83–1.16
CCNE1 19q12	0.89–1.11	0.83–1.17
CHMP2 19q13.43	0.89–1.11	0.83–1.17

*Both 95% and 99% confidence interval corresponding to normal DNA content of all probes are presented. These data were based on 50 DNA samples of blood from healthy controls.