Table 2.
Chr | SNP | Base pair location | p-value | SNPs in LD | Minor allele | MAF | Heritability | Effect size | Closest gene | location |
---|---|---|---|---|---|---|---|---|---|---|
Harm avoidance | ||||||||||
8 | rs11780799 | 103048187 | 1.1 * 10−5 | 2 | A | .47 | .44% | .10 | NCALD | Intronic |
2 | rs10490747 | 207572396 | 1.7 * 10−5 | 1 | A | .29 | .41% | −.10 | DYTN | Intronic |
4 | rs11132986 | 174371781 | 2.0 * 10−5 | 9 | T | .23 | .41% | .11 | Upstream | |
8 | rs17057051 | 27227554 | 2.0 * 10−5 | G | .31 | .42% | .10 | PTK2B | Intronic | |
3 | rs12330727 | 100833748 | 2.5 * 10−5 | 15 | C | .15 | .43% | −.13 | Intergenic | |
3 | rs7625694 | 190117490 | 2.7 * 10−5 | 8 | T | .21 | .39% | .11 | CLDN16 | Intronic |
5 | rs11744339 | 145978081 | 3.3 * 10−5 | G | .12 | .38% | −.14 | PPP2R2B | Intronic | |
18 | rs7231234 | 59362518 | 3.5 * 10−5 | T | .21 | .38% | −.11 | Intergenic | ||
6 | rs1923380 | 165491551 | 3.80 * 10−5 | G | .25 | .39% | −.10 | Intergenic | ||
17 | rs971718 | 13125049 | 3.8 * 10−5 | 2 | C | .04 | .36% | −.23 | Intergenic | |
13 | rs885219 | 29246206 | 4.5 * 10−5 | G | .16 | .37% | .12 | POMP | Intronic | |
4 | rs17008522 | 125652667 | 4.9 * 10−5 | G | .32 | .38% | −.10 | ANKRD50 | Intergenic | |
13 | rs9544495 | 77997413 | 5.0 * 10−5 | A | .34 | .37% | −.09 | Intergenic | ||
Novelty Seeking | ||||||||||
16 | rs4131099 | 51330531 | 3.8 * 10−6 | 4 | A | .22 | .50% | .11 | Intergenic | |
1 | rs3120665 | 152316590 | 4.0 * 10−6 | 21 | G | .16 | .48% | −.14 | Non-coding region | |
9 | rs961831 | 22362104 | 6.6 * 10−6 | 1 | G | .09 | .46% | −.17 | Intergenic | |
15 | rs1533665 | 78530940 | 7.3 * 10−6 | 3 | G | .36 | .45% | −.10 | ACSBG1 | Upstream |
2 | rs10176705 | 50744774 | 9.2 * 10−6 | 5 | T | .37 | .45% | .10 | NRXN1 | Intronic |
3 | rs1835856 | 116491672 | 1.1 * 10−5 | 8 | T | .16 | .43% | −.13 | LSAMP | Intronic |
2 | rs7588898 | 68041842 | 2.0 * 10−5 | 1 | G | .38 | .42% | .10 | Non-coding region | |
Reward Dependence | ||||||||||
5 | rs1078425 | 122673060 | 9.8 * 10−6 | 2 | T | .23 | .43% | −.11 | CEP120 | Intergenic |
3 | rs601007 | 151866461 | 1.3 * 10−5 | 28 | C | .37 | .42% | −.10 | Non-coding region | |
2 | rs6751266 | 126613227 | 2.0 * 10−5 | 4 | T | .13 | .40% | −.14 | Intergenic | |
3 | rs9820712 | 20707225 | 2.1 * 10−5 | 2 | G | .40 | .40% | .09 | Intergenic | |
2 | rs6546442 | 69084118 | 3.2 * 10−5 | 6 | A | .07 | .39% | .17 | BMP10 | Intergenic |
5 | rs922433 | 122937801 | 3.4 * 10−5 | 1 | G | .24 | .36% | −.10 | CSNK1G3 | Intronic |
4 | rs13149354 | 187291107 | 3.6 * 10−5 | A | .24 | .38% | .09 | Intergenic | ||
Persistence | ||||||||||
1 | rs12753569 | 76484014 | 7.6 * 10−6 | 5 | G | .49 | .45% | −.10 | Non-coding region | |
9 | rs7852296 | 126352218 | 8.6 * 10−6 | A | .09 | .44% | −.17 | DENND1A | Intronic | |
13 | rs532238 | 39953327 | 9.9 * 10−6 | A | .29 | .45% | .10 | LHFP | Intronic | |
3 | rs9839894 | 67516139 | 1.4 * 10−5 | 10 | C | .06 | .45% | .20 | SUCLG2 | Intronic |
6 | rs7775434 | 66241186 | 1.4 * 10−5 | 9 | T | .35 | .43% | .10 | EYS | Intronic |
5 | rs13154900 | 49636322 | 1.7 * 10−5 | 2 | C | .14 | .40% | .13 | Intergenic | |
14 | rs17650363 | 82171783 | 1.8 * 10−5 | A | .13 | .42% | −.14 | Intergenic | ||
7 | rs1860735 | 151354400 | 2.1 * 10−5 | T | .11 | .41% | −.14 | PRKAG2 | Intronic | |
12 | rs7955859 | 26339731 | 3.0 * 10−5 | 1 | T | .27 | .38% | −.10 | SSPN | Intergenic |
20 | rs4814041 | 11901222 | 3.0 * 10−5 | 4 | G | .16 | .38% | .12 | BTBD3 | Intronic |
11 | rs2038602 | 33886294 | 4.0 * 10−5 | G | .41 | .37% | −.09 | LMO2 | Synonymous-coding | |
5 | rs1121853 | 155685912 | 4.1 * 10−5 | 3 | G | .07 | .39% | .18 | Intergenic | |
6 | rs9385707 | 135168474 | 4.1 * 10−5 | 3 | C | .26 | .36% | .10 | Intergenic |
Independent markers were those more than 500kb apart and in LD of r2 < 0.70. In nonindependent groups of markers, the most significant is shown, and SNPs_LD is the number of correlated SNPs that are in the top 50. Chr = Chromosome; MAF = Minor Allele Frequency;; Closest gene = name of gene if the SNP is located in a known gene or within 50kb distance from a gene. The base pair locations in this table were obtained from the HapMapI+II (b36r22) CEU legend files, the genes closest to the SNP were obtained from WGA Viewer using release 57.