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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Biol Psychol. 2010 Aug 4;85(2):306–317. doi: 10.1016/j.biopsycho.2010.07.018

Table 2.

Genetic markers showing strongest association with each of Cloninger’s personality scales (independent markers within top 50 SNPs).

Chr SNP Base pair location p-value SNPs in LD Minor allele MAF Heritability Effect size Closest gene location
Harm avoidance
8 rs11780799 103048187 1.1 * 10−5 2 A .47 .44% .10 NCALD Intronic
2 rs10490747 207572396 1.7 * 10−5 1 A .29 .41% −.10 DYTN Intronic
4 rs11132986 174371781 2.0 * 10−5 9 T .23 .41% .11 Upstream
8 rs17057051 27227554 2.0 * 10−5 G .31 .42% .10 PTK2B Intronic
3 rs12330727 100833748 2.5 * 10−5 15 C .15 .43% −.13 Intergenic
3 rs7625694 190117490 2.7 * 10−5 8 T .21 .39% .11 CLDN16 Intronic
5 rs11744339 145978081 3.3 * 10−5 G .12 .38% −.14 PPP2R2B Intronic
18 rs7231234 59362518 3.5 * 10−5 T .21 .38% −.11 Intergenic
6 rs1923380 165491551 3.80 * 10−5 G .25 .39% −.10 Intergenic
17 rs971718 13125049 3.8 * 10−5 2 C .04 .36% −.23 Intergenic
13 rs885219 29246206 4.5 * 10−5 G .16 .37% .12 POMP Intronic
4 rs17008522 125652667 4.9 * 10−5 G .32 .38% −.10 ANKRD50 Intergenic
13 rs9544495 77997413 5.0 * 10−5 A .34 .37% −.09 Intergenic
Novelty Seeking
16 rs4131099 51330531 3.8 * 10−6 4 A .22 .50% .11 Intergenic
1 rs3120665 152316590 4.0 * 10−6 21 G .16 .48% −.14 Non-coding region
9 rs961831 22362104 6.6 * 10−6 1 G .09 .46% −.17 Intergenic
15 rs1533665 78530940 7.3 * 10−6 3 G .36 .45% −.10 ACSBG1 Upstream
2 rs10176705 50744774 9.2 * 10−6 5 T .37 .45% .10 NRXN1 Intronic
3 rs1835856 116491672 1.1 * 10−5 8 T .16 .43% −.13 LSAMP Intronic
2 rs7588898 68041842 2.0 * 10−5 1 G .38 .42% .10 Non-coding region
Reward Dependence
5 rs1078425 122673060 9.8 * 10−6 2 T .23 .43% −.11 CEP120 Intergenic
3 rs601007 151866461 1.3 * 10−5 28 C .37 .42% −.10 Non-coding region
2 rs6751266 126613227 2.0 * 10−5 4 T .13 .40% −.14 Intergenic
3 rs9820712 20707225 2.1 * 10−5 2 G .40 .40% .09 Intergenic
2 rs6546442 69084118 3.2 * 10−5 6 A .07 .39% .17 BMP10 Intergenic
5 rs922433 122937801 3.4 * 10−5 1 G .24 .36% −.10 CSNK1G3 Intronic
4 rs13149354 187291107 3.6 * 10−5 A .24 .38% .09 Intergenic
Persistence
1 rs12753569 76484014 7.6 * 10−6 5 G .49 .45% −.10 Non-coding region
9 rs7852296 126352218 8.6 * 10−6 A .09 .44% −.17 DENND1A Intronic
13 rs532238 39953327 9.9 * 10−6 A .29 .45% .10 LHFP Intronic
3 rs9839894 67516139 1.4 * 10−5 10 C .06 .45% .20 SUCLG2 Intronic
6 rs7775434 66241186 1.4 * 10−5 9 T .35 .43% .10 EYS Intronic
5 rs13154900 49636322 1.7 * 10−5 2 C .14 .40% .13 Intergenic
14 rs17650363 82171783 1.8 * 10−5 A .13 .42% −.14 Intergenic
7 rs1860735 151354400 2.1 * 10−5 T .11 .41% −.14 PRKAG2 Intronic
12 rs7955859 26339731 3.0 * 10−5 1 T .27 .38% −.10 SSPN Intergenic
20 rs4814041 11901222 3.0 * 10−5 4 G .16 .38% .12 BTBD3 Intronic
11 rs2038602 33886294 4.0 * 10−5 G .41 .37% −.09 LMO2 Synonymous-coding
5 rs1121853 155685912 4.1 * 10−5 3 G .07 .39% .18 Intergenic
6 rs9385707 135168474 4.1 * 10−5 3 C .26 .36% .10 Intergenic

Independent markers were those more than 500kb apart and in LD of r2 < 0.70. In nonindependent groups of markers, the most significant is shown, and SNPs_LD is the number of correlated SNPs that are in the top 50. Chr = Chromosome; MAF = Minor Allele Frequency;; Closest gene = name of gene if the SNP is located in a known gene or within 50kb distance from a gene. The base pair locations in this table were obtained from the HapMapI+II (b36r22) CEU legend files, the genes closest to the SNP were obtained from WGA Viewer using release 57.