Figure 1.
Schematic of the device used to load the mouse hindlimb. Compressive loads were applied at the footplate by an electromagnetic actuator and transmitted loads were measured with a load cell at the knee cup. Load was primarily transmitted to the tibia (in white) through the calcaneus distally and the femur proximally (in black). A single element strain gauge bonded at the mid-diaphysis on the medial surface of the tibia measured the strains induced in the tibia as a function of applied load to determine bone stiffness.
