Table 2.

Metabolites concentrations (millimole (mM)) and ratios mean ± standard deviation, in FWM.

	HIV+ (NC) (N= 21)	MCI (N= 31)	HAD (N=34)	P value (ANOVA)	Post-hoc NC versus MCI	Post-hoc NC versus HAD	Post-hoc MCI versus HAD
mI (*)	3.4 ± 0.67	3.86 ± 0.85	4.15±0.75	0.006	ns	<0.05	ns
Cho	1.9 ± 0.39	1.78 ± 0.32	1.83 ± 0.32	ns	ns	ns	ns
Cr	6.04 ± 0.79	5.96 ± 0.8	5.79 ± 0.62	ns	ns	ns	ns
Glu	6.68 ± 1.2	6.3 ± 1.0	6.3 ± 1.1	ns	ns	ns	ns
Gln	4.22 ± 0.4	4.6 ± 1.0	3.82±0.21	ns	sn	ns	ns
Glx (*)	10.0 ± 1.62	9.17 ± 2.1	8.18 ± 2.1	0.006	ns	<0.05	ns
NAA(*)	7.67 ± 0.93	7.6 ± 1.04	7.1 ± 0.93	0.06	ns	ns	ns
mI/Cr (*)	0.56 ± 0.19	0.67 ± 0.19	0.73 ± 0.15	0.004	ns	<0.05	ns
Cho/Cr	0.32 ± 0.05	0.29 ± 0.04	0.32 ± 0.06	ns	ns	ns	ns
Glu/Cr	1.12 ± 0.2	1.06 ± 0.15	1.1 ± 0.2	ns	ns	ns	ns
Glx/Cr (*)	1.67 ± 0.24	1.53 ± 0.26	1.42 ± 0.34	0.01	ns	<0.05	ns
NAA/Cr	1.28 ± 0.15	1.28 ± 0.09	1.23 ± 0.11	ns	ns	ns	ns

FWM = frontal white matter, Cho = choline, Cr = creatine, Glx = combined glutamate (Glu) and glutamine (Gln), NAA = sum of N-acetyl aspartate and N-acetyl aspartyl glutamate, mI = myo-Inositol. Normal cognition (NC), mild cognitive impairment (MCI) and HIV-associated dementia (HAD).

^(*)and values in bold = significant.