The hazard ratios were obtained with Cox’s proportional hazards regression for categorical analysis,23 and were adjusted for age, race, gender, educational status, current smoking status, body mass index, hypertension, time-dependent effect of hypertension, diabetes, dyslipidemia and hemoglobin, as well as interactions between each eGFR and ACR category. Open bars represent the normal ACR category (ACR <10 mg/g), and the darker bars represent high normal, high and very high ACR categories in each eGFR strata. The high normal and high ACR series had significant P values (<0.05) for linear trends when regressed on the median eGFR for each category (*). The linear trend analyses for the normal and very high ACR categories were not significant (P value >0.4).