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. Author manuscript; available in PMC: 2011 Nov 15.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2010 Nov 15;78(4):1244–1252. doi: 10.1016/j.ijrobp.2010.01.039
Target Coverage (TC): TC describes the fraction of the target volume (VT) receiving at
least the prescription dose (VT,presc) and is defined as TC=VT,prescVT.
For perfect coverage, TC equals 1.0.
Homogeneity Index (HI): HI quantifies dose homogeneity in the target volumes, as
recommended by the International Commission on Radiation Units
and Measurements (11). The HI is defined as the greatest dose
delivered to 2% of the target volume (D2%) minus the dose
delivered to 98% of the target volume (D98%) divided by the
median dose (Dmedian) of the target volume: HI=D2%D98%Dmedian
Smaller values of HI correspond to more homogenous irradiation
of the target volume. A value of 0 corresponds to absolute
homogeneity of dose within the target.
V90: V90 quantifies volume of the whole brain PTV receiving 90% of
the prescription dose.
V95: V95 quantifies volume of
the whole brain PTV receiving 95% of the prescription dose.
Mean Normalized Tissue Dose (NTDmean):
NTDmean is defined as the total dose that would have the same
biological effect as the actual treatment schedule, if it were given
in 2 Gy fractions. This parameter allows us to compare the effects
on normal tissue for two dose-volume histograms. An α/β ratio of
2 Gy was assumed for the hippocampus.