| Target Coverage (TC): | TC describes the fraction of the target volume (VT) receiving at least the prescription dose (VT,presc) and is defined as . For perfect coverage, TC equals 1.0. |
| Homogeneity Index (HI): | HI quantifies dose homogeneity in the target volumes, as recommended by the International Commission on Radiation Units and Measurements (11). The HI is defined as the greatest dose delivered to 2% of the target volume (D2%) minus the dose delivered to 98% of the target volume (D98%) divided by the median dose (Dmedian) of the target volume: Smaller values of HI correspond to more homogenous irradiation of the target volume. A value of 0 corresponds to absolute homogeneity of dose within the target. |
| V90: | V90 quantifies volume of the whole brain PTV receiving 90% of the prescription dose. |
| V95: | V95 quantifies volume of the whole brain PTV receiving 95% of the prescription dose. |
| Mean Normalized Tissue Dose (NTDmean): | |
| NTDmean is defined as the total dose that would have the same biological effect as the actual treatment schedule, if it were given in 2 Gy fractions. This parameter allows us to compare the effects on normal tissue for two dose-volume histograms. An α/β ratio of 2 Gy was assumed for the hippocampus. |
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