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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Neuropharmacology. 2010 Sep 8;59(7-8):573–581. doi: 10.1016/j.neuropharm.2010.08.017

Fig. 1. Study design.

Fig. 1

In protocol #1, animals were treated with P (25 mg/kg, s.c., twice daily) for 2 weeks, followed by a P-free (withdrawal) period. In protocol #2, animals were treated with P for 2 weeks, followed by a 1 week washout period. In both studies, animals were kindled daily (except during washout period) until they exhibited three consistent stage 5 seizures.