Table 2.

Metabolite levels of Anterior Brain Regions

		MDD Subjects (N=16)	Healthy Controls (N=38)
Region	Chemica l	mean±SD (mmol/kg)	mean±SD (mmol/kg)	F	p
Left DLPFC Gray Matter	NAA	22.78± 4.20	25.85± 6.79	2.961	0.092
	GPC + PC	3.94± 2.54	3.88± 1.30	0.016	0.899
	PCr + Cr	19.15± 5.87	20.28± 8.92	0.330	0.568
Right DLPFC Gray Matter	NAA	27.08± 7.71	28.91± 7.76	0.645	0.426
	GPC + PC	4.90± 2.64	3.98± 1.53	1.592	0.213
	PCr + Cr	18.89± 6.71	22.82± 7.89	2.709	0.106
Left DLPFC White Matter	NAA	16.82± 5.71	18.28± 6.24	0.900	0.347
	GPC + PC	3.02± 0.97	3.38± 1.08	2.308	0.135
	PCr + Cr	14.22± 5.35	15.48± 5.70	0.768	0.385
Right DLPFC White Matter	NAA	16.81± 4.26	19.38± 6.08	2.967	0.091
	GPC + PC	3.43± 1.42	3.71± 1.40	0.793	0.378
	PCr + Cr	13.53± 3.01	15.01± 5.76	1.205	0.278
Left Medial PFC	NAA	21.22± 5.50	24.20 ± 7.75	1.576	0.216
	GPC + PC	3.21 ± 0.99	4.01± 1.90	2.966	0.092
	PCr + Cr	20.00± 6.56	18.04± 7.85	1.145	0.290
Right Medial PFC	NAA	17.46± 4.08	22.00± 7.59	5.056	0.029
	GPC + PC	3.01± 0.91	3.72± 1.28	4.020	0.051
	PCr + Cr	17.20± 7.04	18.48± 7.22	0.284	0.596
Left Anterior Cingulate	NAA	21.25± 6.56	21.72± 6.86	0.007	0.935
	GPC + PC	4.04± 1.00	4.19± 1.24	0.290	0.593
	PCr + Cr	15.88± 4.71	16.88± 5.34	0.233	0.631
Right Anterior Cingulate	NAA	17.71± 4.40	21.28± 6.37	4.768	0.034
	GPC + PC	3.41± 0.66	4.22± 1.34	7.986	0.007
	PCr + Cr	13.40± 4.14	16.39± 7.05	3.065	0.086
Left Occipital Cortex	NAA	24.92± 7.56	23.38± 9.43	0.1.88	0.667
	GPC + PC	3.90± 2.78	3.44± 2.97	0.056	0.815
	PCr + Cr	18.90± 10.10	16.95± 8.53	0.429	0.516
Right Occipital Cortex	NAA	20.02± 4.68	22.44± 6.97	1.426	0.239
	GPC + PC	2.84± 1.71	3.20± 2.02	0.599	0.444
	PCr + Cr	20.72± 12.28	16.83± 8.62	1.130	0.294