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. 2010 Jul 2;17(11):771–779. doi: 10.1038/cgt.2010.34

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Copyright © 2010 Nature America, Inc.

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Ad.IL-24-Bax suppressed the proliferation of hepatocellular carcinoma cells and induced apoptosis in hepatocellular carcinoma in vivo. (a) The treatment was performed every 3 days for a total of three times for each mouse (n=5) and killed the mice after 3 weeks. Expression of ki-67 in Hep3B tumors was analyzed by immunohistochemistry 3 weeks after the initial injection of transgenic virus, and apoptotic Hep3B cells were detected by transferase-mediated dUTP nick-end-labeling. (b) The number of positive cells was counted as described in Materials and methods. ^*P<0.05, vs the Ad.Luc group. ^#P<0.05 vs the Ad.IL-24 group. The results were expressed as means±s.d. of three randomly selected mice.