Table 1.
Patient and Pathology Specimen Characteristics
| Case_ID (n=36) | Sample_ID (n=57) | Sample age (yrs*) (avg=13) | Pt. age | Pt. sex | Anatomic site | Type | Stain | FNAC diagnosis | DNA yield (μg) (avg=7.4) | Cell yield (×105) (avg=12) | aCGH label | DLR score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LNFNA_11 | LNFNA_11_DQ1 | 16 | 75 | F | Abdomen | FNA | DQ | Cannot rule out lymphoma‡ | 5.0 | 8 | ULS | 0.04 |
| LNFNA_11 | LNFNA_11_P7 | 16 | 75 | F | Abdomen | FNA | P | Cannot rule out lymphoma‡ | 3.9 | 6 | ULS | 0.08 |
| LNFNA_12 | LNFNA_12_DQ1 | 15 | 58 | M | Low back soft tissue | FNA | DQ | Atypical, suspicious for lymphoma | 0.4 | 1 | — | — |
| LNFNA_12 | LNFNA_12_DQ2 | 13 | 58 | M | Low back soft tissue | FNA | DQ | Atypical, suspicious for lymphoma | 5.9 | 10 | ULS | 0.03 |
| LNFNA_12 | LNFNA_12_P3 | 15 | 58 | M | Low back soft tissue | FNA | DQ | Atypical, suspicious for lymphoma | 1.5 | 2 | — | — |
| LNFNA_16 | LNFNA_16_1_DQ3 | 13 | 73 | F | Thyroid | FNA | DQ | Thyroiditis | 3.1 | 5 | ULS | 0.05 |
| LNFNA_17 | LNFNA_17_DQ2 | 15 | 73 | M | Lung | FNA | DQ | Most likely reactive lymphocytes | 1.2 | 2 | ULS | 0.05 |
| LNFNA_17 | LNFNA_17_DQ4 | 13 | 73 | M | Lung | FNA | DQ | Most likely reactive lymphocytes | 4.7 | 8 | ULS | 0.04 |
| LNFNA_17 | LNFNA_17_P4 | 15 | 73 | M | Lung | FNA | P | Most likely reactive lymphocytes | 13.1 | 21 | ULS | 0.06 |
| LNFNA_19 | LNFNA_19_DQ1 | 15 | 76 | F | Thorax | FLUID† | DQ | Benign | 0.1 | 0.2 | — | — |
| LNFNA_19 | LNFNA_19_P1 | 15 | 76 | F | Thorax | FLUID† | P | Benign | 0.1 | 0.2 | — | — |
| LNFNA_2 | LNFNA_2_DQ | 13 | 72 | M | Low back soft tissue | FNA | DQ | Large cell lymphoma | 8.8 | 14 | — | — |
| LNFNA_21 | LNFNA_21_DQ2 | 13 | 73 | M | Retroperitoneum | FNA | DQ | Most consistent with lymphoma‡ | 5.3 | 9 | ULS | 0.05 |
| LNFNA_21 | LNFNA_21_DQ3 | 15 | 73 | M | Retroperitoneum | FNA | DQ | Most consistent with lymphoma‡ | 4.9 | 8 | ULS | 0.04 |
| LNFNA_21 | LNFNA_21_P4 | 15 | 73 | M | Retroperitoneum | FNA | P | Most consistent with lymphoma‡ | 7.6 | 12 | ULS | 0.20 |
| LNFNA_29 | LNFNA_29_2_DQ3 | 12 | 49 | M | Spleen | FNA | DQ | Diffuse large B-cell lymphoma | 3.6 | 6 | ULS | 0.04 |
| LNFNA_3 | LNFNA_3_1_DQ2 | 13 | 59 | M | Thyroid | FNA | DQ | Diffuse large B-cell lymphoma | 1.7 | 3 | ULS | 0.04 |
| LNFNA_32 | LNFNA_32_DQ1 | 13 | 66 | F | Thorax | FLUID† | DQ | B-cell lymphoma NOS | 2.6 | 4 | — | — |
| LNFNA_32 | LNFNA_32_P2 | 13 | 66 | F | Thorax | FLUID† | P | B-cell lymphoma NOS | 0.2 | 0.3 | — | — |
| LNFNA_33 | LNFNA_33_DQ2 | 11 | 64 | M | Abdomen | FNA | DQ | Follicular lymphoma, low grade | 23.3 | 38 | ULS | 0.04 |
| LNFNA_33 | LNFNA_33_DQ2_rep | 11 | 64 | M | Abdomen | FNA | DQ | Follicular lymphoma, low grade | 23.3 | 38 | ULS | 0.27 |
| LNFNA_36 | LNFNA_36_DQ1 | 11 | 66 | M | Pleural Fluid | FLUID† | DQ | Malignant lymphoproliferation | 8.9 | 14 | — | — |
| LNFNA_37 | LNFNA_37_2_DQ2 | 11 | 81 | M | Cervical lymph nodes | FNA | DQ | Many atypical small lymphocytes‡ | 4.8 | 8 | — | — |
| LNFNA_5 | LNFNA_5_DQ | 14 | 78 | M | Retroperitoneum | FNA | DQ | Follicular lymphoma, low grade | 6.3 | 10 | ULS | 0.04 |
| LNFNA_5 | LNFNA_5_DQ_rep | 14 | 78 | M | Retroperitoneum | FNA | DQ | Follicular lymphoma, low grade | 6.3 | 10 | ULS | 0.43 |
| LNFNA_5 | LNFNA_5_P | 14 | 78 | M | Retroperitoneum | FNA | P | Follicular lymphoma, low grade | 6.3 | 10 | ULS | 0.13 |
| LNFNA_52 | LNFNA_52_DQ2 | 12 | 24 | M | Neck mass | FNA | DQ | High-grade B-cell lymphoma | 20.2 | 33 | ULS | 0.04 |
| LNFNA_52 | LNFNA_52_P3 | 12 | 24 | M | Neck mass | FNA | P | High-grade B-cell lymphoma | 15.0 | 24 | ULS | 0.07 |
| LNFNA_59 | LNFNA_59_DQ1 | 12 | 86 | M | Axillary mass | FNA | DQ | High-grade B-cell lymphoma | 2.7 | 4 | ULS | 0.06 |
| LNFNA_59 | LNFNA_59_P1 | 12 | 86 | M | Axillary mass | FNA | P | High-grade B-cell lymphoma | 2.8 | 5 | ULS | 0.17 |
| LNFNA_65 | LNFNA_65_DQ1 | 16 | 84 | M | Submandibular LN | FNA | DQ | Metastatic neoplasm unknown primary | 7.1 | 12 | ULS | 0.22 |
| LNFNA_65 | LNFNA_65_P3 | 16 | 84 | M | Submandibular LN | FNA | P | Metastatic neoplasm unknown primary | 3.5 | 6 | ULS | 0.36 |
| LNFNA_71 | LNFNA_71_DQ1 | 15 | 50 | F | Thyroid | FNA | DQ | Hashimoto's thyroiditis | 9.4 | 15 | — | — |
| LNFNA_71 | LNFNA_71_P6 | 15 | 50 | F | Thyroid | FNA | P | Hashimoto's thyroiditis | 1.1 | 2 | — | — |
| LNFNA_72 | LNFNA_72_DQ1 | 15 | 74 | F | Inguinal LN | FNA | DQ | Large B-cell lymphoma | 8.2 | 13 | ULS | 0.05 |
| LNFNA_72 | LNFNA_72_P3 | 15 | 74 | F | Inguinal LN | FNA | P | Large B-cell lymphoma | 4.2 | 7 | ULS | 0.08 |
| LNFNA_9_2 | LNFNA_9_2_DQ2 | 16 | 67 | F | Thyroid | FNA | DQ | Anaplastic malignant tumor | 1.5 | 2 | ULS | 0.05 |
| LNFNA_9_2 | LNFNA_9_2_P2 | 16 | 67 | F | Thyroid | FNA | P | Anaplastic malignant tumor | 2.0 | 3 | ULS | 0.15 |
| SCLC_10 | SCLC_10_DQ | 12 | 84 | F | Lung | FNA | DQ | Small cell carcinoma | 21.7 | 35 | ENZ | 0.13 |
| SCLC_10 | SCLC_10_P3 | 12 | 84 | F | Lung | FNA | P | Small cell carcinoma | 9.2 | 15 | ULS | 0.40 |
| SCLC_11 | SCLC_11_DQ1 | 11 | 81 | M | Lung | FNA | DQ | Small cell carcinoma | 5.7 | 9 | ENZ | 0.16 |
| SCLC_18_2 | SCLC_18.2_P_T | 14 | 66 | M | Bronchus | BRUSH | P | Small cell carcinoma | 7.5 | 12 | ULS | 0.12 |
| SCLC_25_2 | SCLC_25_2_DQ1 | 11 | 63 | M | Liver | FNA | DQ | Small cell carcinoma | 4.3 | 7 | ENZ | 0.24 |
| SCLC_28_1 | SCLC_28_1_DQ3 | 11 | 68 | F | Liver | FNA | DQ | Small cell carcinoma | 16 | 26 | ULS | 0.06 |
| SCLC_3_2 | SCLC_3_2_DQ_ENZ | 14 | 65 | M | Mediastinum | FNA | DQ | Small cell carcinoma | 8.1 | 13 | ENZ | 0.24 |
| SCLC_3_2 | SCLC_3_2_DQ_ULS | 14 | 65 | M | Mediastinum | FNA | DQ | Small cell carcinoma | 8.1 | 13 | ULS | 0.07 |
| SCLC_49 | SCLC_49_DQ | 11 | 58 | M | Lung | FNA | DQ | Atypical versus reactive | 6.6 | 11 | ULS | 0.06 |
| SCLC_50 | SCLC_50_DQ2 | 11 | 78 | F | Lung | FNA | DQ | Small cell carcinoma | 27.9 | 45 | ULS | 0.18 |
| SCLC_51 | SCLC_51_DQ1 | 11 | 71 | M | Mediastinum | FNA | DQ | Small cell carcinoma | 3.7 | 6 | ENZ | 0.20 |
| SCLC_52 | SCLC_52_DQ2 | 12 | 82 | F | Mediastinum | FNA | DQ | Small cell carcinoma | 1.7 | 3 | ENZ | 0.21 |
| SCLC_53 | SCLC_53_DQ1 | 12 | 60 | M | Mediastinum | FNA | DQ | Lymphoepithelial-like carcinoma | 1.4 | 2 | ENZ | 0.30 |
| SCLC_55 | SCLC_55_DQ1 | 12 | 68 | F | Mediastinum | FNA | DQ | Small cell carcinoma | 2.7 | 4 | ENZ | 0.27 |
| SCLC_6 | SCLC_6_DQ_1 | 13 | 81 | F | Lung | FNA | DQ | Small cell carcinoma | 17.2 | 28 | ENZ | 0.11 |
| SCLC_6 | SCLC_6_P4 | 13 | 81 | F | Lung | FNA | P | Small cell carcinoma | 7.3 | 12 | ULS | 0.09 |
Notes:
LN, lymph node.
*
at time of extraction;
†
filter prep;
‡
subsequent surgical excision diagnosed as lymphoma; — arrayCGH not performed.