Table 3.
Sensitivity, Specificity, Positive Prediction Value (PPV), Negative Prediction Value (NPV), and Area under ROC Curve of Cytology (≥HSIL), High-Risk HPV, and TERC Amplification Analyses for the Diagnosis of High-Grade Cervical Lesions and Invasive Cancer (n = 2316)
| Characteristic | Cytology | High-risk HPV | TERC |
|---|---|---|---|
| Sensitivity, % (95%CI) | 53.9 (51.0–56.8) | 91.3 (89.7–92.9) | 80.7 (78.4–83.0) |
| Specificity, % (95%CI) | 93.3 (91.9–94.7) | 39.3 (36.5–42.1) | 83.8 (81.7–85.9) |
| PPV, % (95%CI) | 88.6 (86.2–91.0) | 59.2 (56.9–61.5) | 82.8 (80.6–85.0) |
| NPV, % (95%CI) | 67.7 (65.5–70.0) | 82.4 (79.2–85.5) | 81.9 (79.7–84.0) |
| Youden's index, % (95%CI) | 47.2 (44.0–50.4) | 30.6 (27.3–33.8) | 64.5 (61.4–67.6) |
| Area under ROC curve, % (95%CI) | 73.6 (71.5–75.7) | 65.3 (63.0–67.5) | 82.3 (80.5–84.1) |
| Kappa value, % (95%CI) | 47.5 (44.2–50.8) | 30.3 (27.0–33.6) | 64.6 (61.5–67.7) |