Table 5.

Sensitivity, Specificity, and NPV of High-Risk HPV, TERC Amplification, and High-Risk HPV + TERC Amplification Analyses for the Diagnosis of CIN2⁺ in Cytologic ASCUS and LSIL Women

Characteristic	Cytology (n)	High-risk HPV	TERC	High-Risk HPV + TERC
Sensitivity, % (95%CI)	ASCUS (660)	89.3 (85.0–93.6)	75.5† (69.5–81.5)	96.4† (93.8–99.0)
	LSIL (601)	95.3 (92.6–98.0)	75.5† (70.0–81.1)	99.1* (98.0–100.0)
Specificity, % (95%CI)	ASCUS (660)	45.5 (40.9–50.0)	86.9† (83.8–89.9)	41.6 (37.1–46.1)
	LSIL (601)	23.4 (19.1–27.7)	78.5† (74.3–82.7)	21.2 (17.0–25.4)
NPV, % (95%CI)	ASCUS (660)	91.0 (87.3–94.6)	89.4 (86.5–92.2)	96.5* (94.0–99.1)
	LSIL (601)	88.7 (82.4–95.0)	83.5 (79.6–87.4)	97.5* (94.1–100.0)

Statistically different from high-risk HPV test

^*P < 0.05,

^†P < 0.01.