Table 6.

Sensitivity, Specificity, and NPV of High-Risk HPV, TERC Amplification, and High-Risk HPV + TERC Amplification Analyses for the Diagnosis of CIN3⁺ in Cytologic ASCUS and LSIL Women

Characteristic	Cytology (n)	High-risk HPV	TERC	High-risk HPV + TERC
Sensitivity, % (95%CI)	ASCUS (660)	92.8 (87.6–97.9)	82.5* (74.9–90.0)	99.0* (97.0–100.0)
	LSIL (601)	96.2 (92.5–99.9)	81.0† (73.4–88.5)	100.0* (100.0–100.0)
Specificity, % (95%CI)	ASCUS (660)	40.0 (35.9–44.0)	77.1† (73.6–80.6)	35.4 (31.4–39.3)
	LSIL (601)	18.8 (15.3–22.2)	65.7† (61.6–69.9)	16.1 (12.9–19.4)
NPV, % (95%CI)	ASCUS (660)	97.0 (94.8–99.2)	96.2 (94.5–98.0)	99.5‡ (98.5–100.0)
	LSIL (601)	95.9 (91.9–99.8)	94.2 (91.8–96.7)	100.0‡ (100.0–100.0)

Statistically different from high-risk HPV test

Statistically higher than TERC amplification

^*P < 0.05,

^†P < 0.01.

^‡P < 0.05.