Table 2.
MicroRNAs that Were Differentially Expressed between MPM and Non-RCC Carcinoma or RCC
| Median values |
MPM versus non-RCC carcinoma (Adeno.) |
MPM versus RCC |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| miR name | MPM | Adeno | RCC | P value | Fold-change | AUC | P value | Fold-change | AUC |
| hsa-miR-200c | 590 | 30000 | 1500 | 2.6E-20 | 50.3 | 0.99 | 5.2E-02 | 2.5 | 0.75 |
| hsa-miR-141 | 260 | 25000 | 990 | 2.9E-20 | 96.6 | 0.99 | 6.7E-02 | 3.8 | 0.75 |
| hsa-miR-200b | 550 | 21000 | 5000 | 2.0E-16 | 38.4 | 0.98 | 7.0E-05 | 9.2 | 0.92 |
| hsa-miR-200a | 880 | 15000 | 4400 | 6.7E-12 | 16.8 | 0.98 | 4.6E-04 | 5 | 0.89 |
| hsa-miR-429 | 73 | 980 | 200 | 2.7E-09 | 13.3 | 0.97 | 4.7E-03 | 2.7 | 0.86 |
| hsa-miR-193a-3p | 6100 | 1500 | 3000 | 3.9E-05 | 4.2 | 0.91 | 6.3E-03 | 2.1 | 0.80 |
| hsa-miR-152 | 2200 | 910 | 1600 | 3.5E-03 | 2.4 | 0.89 | 2.9E-01 | 1.4 | 0.64 |
| hsa-miR-193b | 4300 | 1500 | 2500 | 2.1E-03 | 2.9 | 0.85 | 1.2E-01 | 1.7 | 0.72 |
| hsa-miR-193a-5p | 2000 | 380 | 540 | 2.5E-05 | 5.3 | 0.83 | 6.8E-02 | 3.7 | 0.73 |
| hsa-miR-375 | 120 | 960 | 82 | 7.0E-03 | 7.8 | 0.82 | 4.4E-01 | 1.5 | 0.63 |
| hsa-miR-194 | 280 | 1900 | 2400 | 7.9E-03 | 6.8 | 0.81 | 3.3E-04 | 8.6 | 0.94 |
| hsa-miR-221 | 19000 | 12000 | 7800 | 3.9E-03 | 1.6 | 0.79 | 5.2E-03 | 2.5 | 0.88 |
| hsa-miR-192 | 410 | 1800 | 3000 | 1.8E-02 | 4.5 | 0.76 | 1.1E-03 | 7.4 | 0.91 |
| hsa-miR-494 | 3100 | 1600 | 1300 | 2.8E-02 | 2 | 0.76 | 1.2E-02 | 2.4 | 0.8 |
| hsa-miR-143 | 7400 | 13000 | 17000 | 4.8E-02 | 1.8 | 0.74 | 1.6E-03 | 2.3 | 0.92 |
| hsa-miR-130a | 10000 | 3500 | 5200 | 4.7E-02 | 2.9 | 0.73 | 9.2E-02 | 1.9 | 0.75 |
| hsa-miR-30 days | 8800 | 12000 | 20000 | 1.1E-01 | 1.4 | 0.67 | 1.3E-04 | 2.2 | 0.94 |
| hsa-miR-497 | 1300 | 2600 | 5500 | 2.1E-01 | 2 | 0.64 | 9.0E-03 | 4.3 | 0.85 |
| hsa-miR-210 | 5900 | 4000 | 13000 | 2.9E-01 | 1.5 | 0.61 | 3.0E-03 | 2.2 | 0.88 |
| hsa-miR-30a | 7400 | 6100 | 16000 | 4.6E-01 | 1.2 | 0.58 | 5.4E-04 | 2.2 | 0.93 |
| hsa-miR-486-5p | 500 | 590 | 1600 | 4.3E-01 | 1.2 | 0.56 | 4.2E-03 | 3.2 | 0.84 |
| hsa-miR-451 | 1300 | 1200 | 2900 | 8.1E-01 | 1.1 | 0.51 | 2.7E-02 | 2.2 | 0.80 |
| hsa-miR-10b | 350 | 300 | 1200 | 8.3E-01 | 1.2 | 0.5 | 2.3E-02 | 3.4 | 0.85 |
| hsa-miR-126 | 4300 | 5100 | 15000 | 7.8E-01 | 1.2 | 0.49 | 3.7E-03 | 3.5 | 0.87 |
Median values of normalized fluorescence (rounded to two significant digits) in MPM, non-RCC carcinoma (all Adeno. in this set), and RCC samples are shown for microRNAs that were differentially expressed between MPM and either non-RCC carcinoma or RCC, as measured on the microarray platform. A Benjamini-Hochberg false discovery rate of 0.2 was used to identify differentially expressed microRNAs, resulting in P value cutoffs of 0.05 and 0.04 for adenocarcinoma and RCC, respectively. For each of the two comparisons, P values are shown (two-sided unpaired t-test), fold-change of median expression (either up-regulated or down-regulated, as is evident from the median values), and AUC, which is the area under the receiver operating characteristic (ROC) curve, indicative of the classification potential of each microRNA. MicroRNAs are sorted by decreasing values of the AUC of the comparison from MPM versus non-RCC carcinoma.