Table 5.

IRF-1 Single Nucleotide Polymorphisms (SNPs) genotyped for the case-control study and their frequency in Healthy Population Controls, Mild Malaria Cases and Severe Malaria Cases from Burkina Faso.

			Healthy Population Controls		Mild Malaria Cases		Severe Malaria Cases
SNP	Alleles	FR %	MAF	HWE	MAF	HWE	MAF	HWE
rs10065633	T/C	5.9	49.4±1.8	0.48	47.7±2.5	0.91	56.5±2.9	0.38
rs10213701	A/T	4.7	33.6±1.7	0.78	35.1±2.4	0.52	40.2±2.8	0.71
rs2706384	C/A	8.5	42.7±1.8	0.64	45.6±2.5	0.60	42.3±2.9	0.12

The 3 markers were selected among the initial 14 for being haplotype-tagging SNPs and/or showing an association signal in the Mossi population, as well as on the basis of their gene location (one 5′ upstream, one intronic, one 3′ downstream, see Table 1).

Abbreviations: FR %, genotyping failure rate; MAF, Minor Allele Frequency; HWE, Hardy-Weinberg Equilibrium test p value.