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. 2010 Oct 21;5:867–873. doi: 10.2147/IJN.S13273

Figure 3.

Figure 3

Nanoemulsions formulated with low-energy spontaneous emulsification. A) Surfactant = Cremophor ELP®, oil = Labrafil M 1944 CS®. B) Surfactant = Solutol HS15, oil = Labrafac CC®. Hydrodynamic diameter and polydispersity index (PDI; inset) are plotted against the surfactant/oil weight ratio (SOR). Nanoemulsions-encapsulating the drug (diclofenac) are shown with the filled circles and compared with a formulation of “empty” nanoemulsions (open diamond-shaped symbols). The gray parts indicate that the criteria of PDI quality are not met, and the suspension cannot be considered as a nanoemulsion. Relative standard deviations are comprised as follows: A) for empty nanoemulsions, between 1.5% and 0.2%; and for loaded nanoemulsions, between 4.3% and 3.5%; B) for empty nanoemulsions, between 1.3% and 0.1%; and for loaded nanoemulsions, between 3.8% and 2.2%.