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. Author manuscript; available in PMC: 2010 Oct 26.
Published in final edited form as: Transplantation. 1991 Jan;51(1):275–278. doi: 10.1097/00007890-199101000-00048

Figure 1.

Figure 1

The acute effect of FK506 on 16.7 mM glucose–induced insulin release. In this and subsequent figures insulin release was measured at the end of a 90-min incubation in all conditions. Values are expressed as the mean ± SEM from 36 batches of islets. In this and subsequent figures, 100% secretion corresponds to insulin measured in 16.7 mM glucose after subtraction of basal release. Basal (2.8 mM glucose induced) insulin release was 650±5.8 pg/islet/90 min and stimulated (16.7 mM glucose induced) release was 2208±20.9 pg/islet/90 min (P<0.01). A concentration of 100 ng/ml FK506 produced an average inhibition of 35% (P<0.05). This concentration was inhibitory in every experiment. In one experiment, a concentration of 10 ng/ml was also significantly inhibitory.