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. Author manuscript; available in PMC: 2010 Oct 26.
Published in final edited form as: Transplantation. 1991 Jan;51(1):275–278. doi: 10.1097/00007890-199101000-00048

Figure 3.

Figure 3

The combined effect of CsA and FK506 on glucose-induced insulin release. Results are expressed as the mean ± SEM from 12 batches of islets. Basal (2.8 mM glucose–induced) insulin release was 268±8.5 pg/islet/90 min, and stimulated (16.7 mM glucose induced) release was 1288±11.4 pg/islet/90 min (P<0.01). CsA produced a 40% and 50% reduction of glucose-induced insulin release at 1 and 10 μg/ml, respectively (P<0.05). The effects of CsA at either concentration and FK506 (1 ng/ml) were not additive to inhibit insulin release further.