Table 1.
In vitro sensitivities to artemether and lumefantrine and distribution of pfmdr1 polymorphisms of the 96 recently adapted parasites from different areas
| Area | No. of isolates | Artemether IC50 (nM) | Lumefantrine IC50 (nM) | pfmdr1 copy number | pfmdr1 mutations | ||||
|---|---|---|---|---|---|---|---|---|---|
| 86Y | 184F | 1034C | 1042D | 1246Y | |||||
| Tak | 27 | 4.3 ± 2.0 | 147.7 ± 116.4 | 3.2 ± 1.7 | 1 (3.7%) | 7 (25.9%) | – | – | – |
| Kanchanaburi | 26 | 3.3 ± 2.0 | 94.8 ± 72.9 | 2.4 ± 1.1 | 5 (19.2%) | 9 (34.6%) | 2 (7.7%) | 2 (7.7%) | – |
| Ranong | 16 | 4.0 ± 2.4 | 96.5 ± 65.5 | 3.0 ± 1.0 | 1 (6.3%) | 6 (37.5%) | 2 (12.5%) | 2 (12.5%) | – |
| Chantaburi | 27 | 2.7 ± 2.0 | 122.2 ± 111.5 | 1.7 ± 1.1 | 5 (18.5%) | 21 (77.8%) | 6 (22.2%) | 10 (37.0%) | – |
| Total | 96 | 3.5 ± 2.1 | 117 ± 98.3 | 2.5 ± 1.4 | 12 (12.5%) | 43 (44.8%) | 10 (10.4%) | 14 (14.6%) | – |