Table 2.
Comparison of lumenfantrine and artemether sensitivity among P. falciparum with different pfmdr1 genotypes
| pfmdr1 genotypes | No. | Lumefantrine IC50 (nM) | P value | Artemether IC50 (nM) | P value | |
|---|---|---|---|---|---|---|
| 86 | N86 | 86 | 125.7 ± 100.4 | < 0.001 | 3.7 ± 2.2 | < 0.001 |
| 86Y | 15 | 56.8 ± 36.3 | 2.1 ± 1.1 | |||
| 184 | Y184 | 57 | 102.6 ± 80.5 | 0.145 | 3.8 ± 2.3 | 0.120 |
| 184F | 44 | 132.2 ± 113.3 | 3.1 ± 1.8 | |||
| 1034 | S1034 | 91 | 121.9 ± 99.5 | < 0.001 | 3.7 ± 2.1 | < 0.001 |
| 1034C | 10 | 57.3 ± 29.1 | 1.7 ± 1.1 | |||
| 1042 | N1042 | 87 | 120.7 ± 94.6 | 0.180 | 3.7 ± 2.1 | 0.004 |
| 1042D | 14 | 83.2 ± 54.5 | 2.0 ± 1.9 | |||
| Copy no. | < 4 | 85 | 101.7 ± 85.6 | 0.013 | 3.2 ± 2.0 | 0.026 |
| ≥ 4 | 16 | 188.9 ± 120.7 | 4.5 ± 2.2 |
IC50 values are shown as mean values ± standard deviation.