Table 3.
Univariate and multivariate analysis of the association between pfmdr1 genotypes and decreased lumefantrine susceptibility
| Genotypes | No. (%) | Prevalence of decreased lumefantrine susceptibility (%) | Crude odds ratio (95% CI) | P value | Adjusted odds ratio (95% CI) | P value |
|---|---|---|---|---|---|---|
| 86Y | 15 (14.9) | 0 (0) | 1 | 0.019 | ||
| N86 | 86 (85.1) | 25 (29.1) | 1.2 (1.1–1.4) | |||
| Y184 | 57 (56.4) | 11 (19.3) | 1 | 0.169 | 1 | 0.009 |
| 184F | 44 (43.6) | 14 (31.8) | 1.4 (0.9–2.2) | 4.2 (1.4–12.5) | ||
| 1034C | 10 (9.9) | 0 (0) | 1 | 0.063 | ||
| S1034 | 91 (90.1) | 25 (27.5) | 1.2 (1.1–1.3) | |||
| 1042D | 14 (13.9) | 1 (7.1) | 1 | 0.179 | 1 | 0.044 |
| N1042 | 87 (86.1) | 24 (27.6) | 1.2 (1.0–1.3) | 9.7 (1.18–8.1) | ||
| Copy no. < 4 | 85 (84.2) | 17 (20) | 1 | 0.023 | 1 | 0.006 |
| Copy no. ≥ 4 | 16 (15.8) | 8 (50) | 3.0 (1.3–7.3) | 5.6 (1.6–19.6) |