Table 2.
Number and percentage of amino acid and nucleotide substitutions among each gene and 5′ and 3′ non-translated regions of 10 Thai dengue virus serotype 1 strains, Thailand*
| Viruses | No. (%) aa substitutions | No. (%) aa substitutions in each gene | No. (%) nt differences in 3′ NTR (462 nt)† | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C (114 aa) | prM/M (166 aa) | E (495 aa) | NS1 (352 aa) | NS2A (218 aa) | NS2B (130 aa) | NS3 (619 aa) | NS4A (150 aa) | NS4B (249 aa) | NS5 (899 aa) | |||
| ThD1-0442-80‡ | 80 (2.4) | 3 (2.63) | 5 (3.01) | 15 (3.03) | 11 (3.13) | 12 (5.50) | 1 (0.77) | 12 (1.94) | 3 (2.00) | 4 (1.61) | 14 (1.56) | 18 (3.90) |
| ThD1-0673-80‡ | 78 (2.3) | 3 (2.63) | 6 (3.61) | 13 (2.63) | 11 (3.13) | 12 (5.50) | 1 (0.77) | 11 (1.78) | 4 (2.67) | 4 (1.61) | 13 (1.45) | 18 (3.90) |
| ThD1-0008-81§ | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| ThD1-0081-82§ | 12 (0.35) | 0 (0) | 1 (0.60) | 1 (0.20) | 0 (0) | 2 (0.92) | 0 (0) | 6 (0.97) | 0 (0) | 1 (0.40) | 1 (0.11) | 1 (0.22) |
| ThD1-0323-91§ | 25 (0.74) | 2 (1.75) | 0 (0) | 3 (0.61) | 1 (0.28) | 5 (2.29) | 0 (0) | 3 (0.48) | 0 (0) | 1 (0.40) | 10 (1.11) | 4 (0.87) |
| ThD1-0336-91§ | 23 (0.68) | 2 (1.75) | 0 (0) | 4 (0.81) | 1 (0.28) | 6 (2.75) | 0 (0) | 3 (0.48) | 0 (0) | 1 (0.40) | 6 (0.67) | 1 (0.22) |
| ThD1-0097-94§ | 29 (0.85) | 1 (0.88) | 2 (1.20) | 6 (1.21) | 3 (0.85) | 4 (1.83) | 0 (0) | 4 (0.65) | 2 (1.33) | 2 (0.80) | 5 (0.56) | 7 (1.52) |
| ThD1-0488-94§ | 32 (0.94) | 3 (2.63) | 3 (1.80) | 6 (1.21) | 3 (0.85) | 4 (1.83) | 1 (0.77) | 4 (0.65) | 2 (1.33) | 1 (0.40) | 5 (0.56) | 7 (1.52) |
| ThD1-0049-01§ | 47 (1.39) | 3 (2.63) | 2 (1.20) | 8 (1.62) | 5 (1.42) | 4 (1.83) | 0 (0) | 6 (0.97) | 1 (0.67) | 3 (1.20) | 15 (1.67) | 9 (1.95) |
| ThD1-0102-01§ | 45 (1.33) | 2 (1.75) | 2 (1.20) | 7 (1.41) | 5 (1.42) | 4 (1.83) | 0 (0) | 6 (0.97) | 1 (0.67) | 3 (1.20) | 15 (1.67) | 9 (1.95) |
*
aa = amino acid; prM/M = premembrane/membrane; E = envelope; NS = nonstructural; nt = nucleotide; NTR = non-translated region.
†
There were no nucleotide differences in the 5′NTR.
‡
Genotype III.
§
Genotype I.