Table 3.
Viruses | ThD1-0442-80 | ThD1-0673-80 | ThD1-0008-81 | ThD1-0081-82 | ThD1-0323-91 | ThD1-0336-91 | ThD1-0097-94 | ThD1-0488-94 | ThD1-0102-01 | ThD1-0049-01 |
---|---|---|---|---|---|---|---|---|---|---|
Disease severity | DHF I | DF | DHF II | DF | DHF III | DF | DHF II | DF | DHF II | DF |
Epidemic† | High | High | Low | Low | Intermediate | Intermediate | Low | Low | High | High |
Genotypes | III | III | I | I | I | I | I | I | I | I |
C (114 aa) | ||||||||||
(AA9) | G | G | G | G | G | G | A | A | A | A |
(AA26) | (G) | (G) | V | V | V | V | V | V | V | V |
(AA90) | (S) | (S) | N | N | N | N | N | N | N | N |
(AA112) | A | A | A | A | [V] | [V] | A | A | A | A |
prM/M (166 aa) | ||||||||||
(AA15) | S | S | T | T | T | T | S | S | S | S |
(AA118) | (R) | (R) | K | K | K | K | K | K | K | K |
(AA122) | (K) | (K) | R | R | R | R | R | R | R | R |
(AA143) | (T) | (T) | A | A | A | A | A | A | A | A |
E (495 aa) | ||||||||||
(AA8) | N | N | N | N | N | N | S | S | S | S |
(AA37) | (N)‡ | (N)‡ | D | D | D | D | D | D | D | D |
(AA155) | (T) | (T) | S | S | S | S | S | S | S | S |
(AA161) | (I) | (I) | T | T | T | T | T | T | T | T |
(AA225) | S | S | S | S | [T] | [T] | S | S | S | S |
(AA272) | (M) | (M) | T | T | T | T | T | T | T | T |
(AA297) | (V) | (V) | M | M | M | M | M | M | M | M |
(AA324) | V | V | V | V | V | V | I | I | I | I |
(AA343) | K | K | K | K | K | K | R | R | K | K |
(AA351) | L | L | V | V | V | V | L | L | L | L |
(AA369) | (T) | (T) | A | A | A | A | A | A | A | A |
(AA380) | I | I | V | V | V | V | I | I | I | I |
(AA397) | S | S | S | S | [T] | [T] | S | S | S | S |
(AA439) | (V) | (V) | I | I | I | I | I | I | I | I |
(AA461) | (I) | (I) | V | V | V | V | V | V | V | V |
(AA484) | (M) | (M) | L | L | L | L | L | L | L | L |
NS1 (352 aa) | ||||||||||
(AA93) | (A) | (A) | V | V | V | V | V | V | V | V |
(AA94) | (N) | (N) | S | S | S | S | V | V | A | A |
(AA98) | (T) | (T) | A | A | A | A | A | A | A | A |
(AA128) | (I) | (I) | V | V | V | V | V | V | V | V |
(AA139) | (D)‡ | (D)‡ | N | N | N | N | N | N | N | N |
(AA178) | (M) | (M) | V | V | V | V | V | V | V | V |
(AA224) | I | I | V | V | V | V | V | V | I | I |
(AA227) | (R) | (R) | K | K | K | K | K | K | K | K |
(AA286) | V | V | I | I | V | V | V | V | V | V |
(AA347) | (R) | (R) | K | K | K | K | K | K | K | K |
NS2A (218 aa) | ||||||||||
(AA2) | S | S | S | L | L | L | S | S | S | S |
(AA15) | (V) | (V) | I | I | I | I | I | I | I | I |
(AA41) | F | F | L | L | L | L | L | L | F | F |
(AA64) | (V) | (V) | A | A | A | A | A | A | A | A |
(AA133) | (M) | (M) | I | I | I | I | I | I | I | I |
(AA147) | (T) | (T) | A | A | A | A | A | A | A | A |
(AA148) | T | T | A | A | A | A | T | T | T | T |
(AA155) | I | I | I | I | I | I | V | V | I | I |
(AA159) | (L) | (L) | Y | Y | F | F | F | F | F | F |
(AA162) | (D)‡ | (D)‡ | H | H | H | H | H | H | H | H |
(AA168) | (I) | (I) | M | M | M | M | M | M | M | M |
(AA182) | L | L | L | L | [M] | [M] | L | L | L | L |
(AA199) | (F) | (F) | L | L | L | L | L | L | L | L |
(AA210) | (T) | (T) | A | A | A | A | A | A | A | A |
NS2B (130 aa) | ||||||||||
(AA112) | (M) | (M) | L | L | L | L | L | L | L | L |
NS3 (619 aa) | ||||||||||
(AA26) | (L) | (L) | M | M | M | M | M | M | M | M |
(AA43) | (D) | (D) | E | E | E | E | E | E | E | E |
(AA44) | (G) | (G) | N | N | N | N | N | N | N | N |
(AA85) | (F) | (F) | L | L | L | L | L | L | L | L |
(AA112) | (T) | (T) | A | A | A | A | A | A | A | A |
(AA185) | (K) | (K) | R | R | R | R | R | R | R | R |
(AA255) | (R) | (R) | K | K | K | K | K | K | K | K |
(AA293) | (A) | (A) | S | S | S | S | S | S | S | S |
(AA323) | V | V | V | V | V | V | V | V | M | M |
(AA350) | D | D | D | D | D | D | E | E | E | E |
(AA368) | S | S | S | S | S | S | S | S | A | A |
(AA466) | Q | Q | Q | Q | Q | Q | H | H | H | H |
NS4A (150 aa) | ||||||||||
(AA19) | (L) | (L) | Q | Q | Q | Q | Q | Q | Q | Q |
(AA39) | (K) | (K) | R | R | R | R | R | R | R | R |
(AA76) | K | K | R | R | R | R | K | K | K | K |
(AA93) | V | V | V | V | V | V | A | A | V | V |
NS4B (249 aa) | ||||||||||
(AA19) | (V) | (V) | A | A | A | A | A | A | A | A |
(AA20) | (A) | (A) | V | V | V | V | V | V | V | V |
(AA27) | T | T | T | T | T | T | T | T | A | A |
(AA31) | (I) | (I) | V | V | V | V | V | V | V | V |
(AA148) | V | V | V | V | V | V | V | V | I | I |
NS5 (899 aa) | ||||||||||
(AA34) | M | M | M | M | [I] | [I] | M | M | M | M |
(AA108) | P | P | A | A | A | A | P | P | P | P |
(AA127) | Y | Y | Y | Y | Y | Y | Y | Y | H | H |
(AA135) | T | T | T | T | T | T | T | T | I | I |
(AA270) | (I) | (I) | V | V | V | V | V | V | V | V |
(AA285) | (N) | (N) | H | H | H | H | H | H | H | H |
(AA325) | R | R | R | R | R | R | K | K | K | K |
(AA365) | (P) | (P) | A | A | A | A | A | A | A | A |
(AA367) | R | R | Q | Q | Q | Q | R | R | R | R |
(AA372) | I | I | I | I | [V] | [V] | I | I | I | I |
(AA378) | K | K | K | R | R | R | R | R | R | R |
(AA428) | E | E | E | E | E | E | E | E | D | D |
(AA513) | K | K | K | K | [R] | [R] | K | K | K | K |
(AA565) | T | T | T | T | T | T | T | T | K | K |
(AA585) | (S) | (S) | N | N | N | N | N | N | N | N |
(AA616) | (V) | (V) | A | A | A | A | A | A | A | A |
(AA631) | S | S | S | S | S | S | S | S | N | N |
(AA635) | (N) | (N) | T | T | T | T | T | T | T | T |
(AA636) | (S) | (S) | P | P | P | P | P | P | P | P |
(AA649) | (H)‡ | (H)‡ | Y | Y | Y | Y | Y | Y | Y | Y |
(AA669) | (T) | (T) | I | I | I | I | I | I | I | I |
(AA746) | S | S | S | S | S | S | S | S | G | G |
(AA807) | D | D | N | N | N | N | D | D | D | D |
(AA891) | E | E | E | E | [D] | [D] | E | E | E | E |
3′ NTR (462 nt) | ||||||||||
(nt2) | C | C | C | C | C | C | T | T | T | T |
(nt3) | C | C | T | T | T | T | C | C | C | C |
(nt10) | C | C | T | T | T | T | C | C | C | C |
(nt12) | (C) | (C) | T | T | T | T | T | T | T | T |
(nt14) | T | T | C | C | T | T | C | C | C | C |
(nt15) | (G) | (G) | A | A | A | A | A | A | A | A |
(nt31) | (G) | (G) | A | A | A | A | A | A | A | A |
(nt32) | (A) | (A) | G | G | G | G | G | G | G | G |
(nt38) | A | A | T | T | T | T | A | A | A | A |
(nt44) | (A) | (A) | G | G | G | G | G | G | G | G |
(nt45) | (A) | (A) | G | G | G | G | G | G | G | G |
(nt62) | (T) | (T) | A | A | A | A | A | A | A | A |
(nt167) | (G) | (G) | A | A | A | A | A | A | A | A |
(nt193) | (C) | (C) | T | T | T | T | T | T | T | T |
(nt262) | A | A | A | A | A | A | A | A | G | G |
(nt264) | (G) | (G) | A | A | A | A | A | A | A | A |
(nt268) | C | C | C | C | C | C | T | T | T | T |
(nt347) | (C) | (C) | T | T | T | T | T | T | T | T |
NTR = non-translated region; DHF = dengue hemorrhagic fever; DF = dengue fever; aa = amino acid; prM/M = premembrane/membrane; E = envelope; NS = nonstructural; NTR = nontranslated region; nt = nucleotide. Bold letters indicate amino acid/nucleotide evolution. Letters in parentheses indicate amino acid substitutions observed among viruses sampled only from genotype III strains. Letters in brackets indicate amino acid substitutions observed among viruses sampled only from the intermediate epidemic.
High, low, and intermediate indicate different dengue epidemic periods based on the rate of total dengue cases sampled at the Queen Sirikit National Institute of Child Health, Bangkok, Thailand during 1973–2001.
Indicates the charge change of the amino acids.