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. 2010 Nov 1;137(21):3561–3568. doi: 10.1242/dev.053728

Fig. 3.

Fig. 3.

Su(H) is a repressor of hh expression in hemocyte precursors within the medullary zone. (A,B) Su(H) is strongly expressed in prohemocytes present in the medullary zone (MZ), and weakly expressed in differentiated hemocytes and hhF4f-GFP-positive niche cells. (C-E) Mutation of the evolutionarily conserved Su(H) recognition sequence in the hhF4fmSu(H)-GFP DNA results in the de novo appearance of the GFP reporter in prohemocytes in the MZ, as compared with eater-DsRed expression in plasmatocytes in the cortical zone (CZ). (F,G) Expansion of hh PSC enhancer activity, and ectopic expression of Hh protein, in medullary zone cells in an Su(H) loss-of-function mutant background. (H) In the same Su(H) mutant background, a normal PSC cell population is maintained, as Antp protein expression is not expanded. Scale bar: 20 μm.