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. 2010 Sep 7;6:411. doi: 10.1038/msb.2010.62

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Copyright © 2010, EMBO and Macmillan Publishers Limited

This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.

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Functional flux mode for the synthesis of glycocholate. Flux distribution obtained for canalicular glycocholate as target flux using the minimal exchange set. Metabolites are labeled and color coded according to their sub-cellular localization (s, sinusoidal; c, cytosol; r, endoplasmic reticulum; m, mitochondrion; b, bile). All internal metabolites are balanced, including cofactors, which may appear in several instances in the graph. Reaction arrows correspond to flux direction and magnitude predicted by TR-FBA and reaction identifiers are indicated. The flux graph was created with the program CytoScape (Shannon et al, 2003; Killcoyne et al, 2009) and our own CytoScape plug-in FluxViz (König and Holzhütter, 2010).