TABLE 2.

Representative study of effect of prednisolone on renal handling of sodium in a Brattleboro rat undergoing water diuresis with individual urine collections from left (L) and right (R) kidney

Time, min	Body Wt 250 g
	V, μl/min		CIn, μl/min		UNaV, μEq/min		CNa/CIn × 100		Uosm, mOsm/kg H2O		Cosm, μl/min		CH2O/CIn × 100
	L	R	L	R	L	R	L	R	L	R	L	R	L	R
0	Prime with inulin 5 mg/100 g and continue sustaining infusion delivering inulin 10 mg/100 g per hr in 0.4% NaCl at rate of 3 ml/100 g per hr
0–300	Equilibration period
300–320	43	55	690	740	0.21	0.22	0.20	0.22	62	75	11.3	17.5	4.6	5.0
320–340	40	50	710	700	0.26	0.16	0.26	0.14	64	76	10.8	16.2	4.2	4.8
340–360	45	55	775	730	0.23	0.16	0.20	0.14	60	78	11.4	18.1	5.3	5.0
	Begin infusion of prednisolone 0.25 mg/100 g per hr into left renal artery
360–380	55	55	660	715	0.44	0.22	0.48	0.17	74	75	17.5	17.7	5.7	5.0
380–420	63	57	661	730	0.66	0.28	0.73	0.26	93	76	25.3	17.9	5.8	4.8
420–440	70	63	702	760	0.91	0.60	1.00	0.50	102	80	31.0	20.0	5.6	5.1
	Discontinue prednisolone infusion
440–460	79	68	710	710	1.00	0.62	1.10	0.65	104	92	35.0	25.0	6.2	6.0
460–480	68	59	700	740	0.81	0.65	0.82	0.64	96	89	30.0	25.2	5.4	5.1