TABLE 3.

Representative study effect of prednisolone on renal handling of sodium in a rat undergoing distal tubular blockade with individual urine collection from left (L) and right (R) kidneys

Time, min	Body Wt 200 g
	V, μl/min		CIn, μl/min		UNaV, μEq/min		CNa/CIn × 100
	L	R	L	R	L	R	L	R
0	Prime with inulin 5 mg/100 g and continue sustaining infusion of inulin 10 mg/100 g/hr with chlorothiazide 4 mg/hr and ethacrynic acid 7 mg/hr with normal saline at rate of 3 ml/100 g per hr
0–300	Equilibration
300–320	50	40	338	420	6.8	6.8	13.6	11.0
320–340	50	40	292	350	6.6	6.5	15.4	12.5
	Begin infusion of prednisolone 0.25 mg/100 g per hr into left renal artery
340–360	70	43	287	370	8.8	6.2	21.3	11.5
360–380	75	60	286	343	9.8	7.8	23.4	16.0
380–400	83	70	303	370	10.4	8.8	24.1	16.8
	Discontinue prednisolone infusion
400–420	70	63	233	305	10.0	8.4	29.9	19.5
420–440	70	63	317	380	9.1	8.3	20.2	15.3