TABLE 5.
Control |
Prednisolone |
Control |
Control |
Prednisolone |
Control |
Control |
Prednisolone |
Control |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
L | R | L | R | L | R | L | R | L | R | L | R | L | R | L | R | L | R | |
A) Six hydropenic rats | ||||||||||||||||||
R1 | R3 | R5 | ||||||||||||||||
SNa, mEq/liter | 143 | 144 | 144 | 145 | 140 | 145 | 144 | 144 | 145 | |||||||||
V, μl/min | 10.0 | 10.0 | 18.3 | 10.8 | 20.0 | 11.7 | 6.7 | 8.3 | 16.7 | 10.8 | 14.2 | 10.0 | 11.7 | 8.3 | 19.2 | 10.2 | 16.7 | 10.0 |
UNaV, μEq/min | 0.29 | 0.24 | 3.36 | 0.81 | 4.15 | 1.21 | 0.19 | 0.23 | 3.17 | 2.15 | 1.34 | 0.77 | 0.17 | 0.11 | 1.48 | 0.15 | 0.13 | 0.15 |
Uosm, mOsm/kg H2O | 1,340 | 910 | 1,105 | 972 | 1,125 | 1,002 | 1,188 | 1,100 | 907 | 1,180 | 1,157 | 1,440 | 430 | 415 | 450 | 380 | 465 | 380 |
Cosm, μl/min | 46.0 | 28.2 | 63.0 | 33.2 | 70.0 | 37.7 | 26.5 | 30.5 | 47.5 | 38.2 | 51.4 | 46.0 | 16.1 | 11.0 | 25.8 | 12.4 | 24.5 | 12.0 |
CIn, μl/min | 650 | 632 | 633 | 632 | 578 | 581 | 656 | 770 | 800 | 800 | 797 | 856 | 403 | 535 | 390 | 426 | 354 | 388 |
R2 | R4 | R6 | ||||||||||||||||
SNa, mEq/liter | 140 | 141 | 140 | 135 | 136 | 136 | 140 | 142 | 143 | |||||||||
V, μl/min | 9.2 | 8.3 | 19.2 | 10.8 | 14.2 | 9.1 | 10.0 | 8.3 | 18.3 | 10.8 | 15.0 | 10.8 | 7.5 | 6.5 | 28.2 | 7.4 | 16.5 | 8.1 |
UNaV, μEq/min | 0.30 | 0.15 | 0.53 | 0.14 | 0.55 | 0.28 | 0.23 | 0.17 | 1.01 | 0.26 | 0.63 | 0.13 | 0.26 | 0.17 | 1.91 | 0.72 | 1.36 | 0.51 |
Uosm, mOsm/kg H2O | 903 | 765 | 726 | 780 | 730 | 968 | 507 | 572 | 500 | 524 | 500 | 599 | 1,345 | 1,299 | 881 | 1,850 | 1,190 | 1,820 |
Cosm, μl/min | 26.1 | 20.5 | 44.5 | 26.8 | 31.3 | 28.3 | 17.0 | 17.2 | 30.2 | 19.0 | 24.1 | 21.6 | 32.4 | 26.0 | 75.4 | 43.2 | 55.0 | 42.7 |
CIn, μl/min | 568 | 603 | 503 | 466 | 430 | 455 | 511 | 581 | 497 | 494 | 514 | 580 | 749 | 810 | 744 | 800 | 736 | 823 |
B) Six rats with diabetes insipidus | ||||||||||||||||||
RD1 | RD3 | RD5 | ||||||||||||||||
SNa, mEq/liter | 140 | 141 | 140 | 139 | 139 | 140 | 130 | 133 | 133 | |||||||||
V, μl/min | 43.0 | 53.3 | 62.3 | 58.2 | 73.5 | 63.5 | 47.5 | 43.0 | 93.5 | 45.0 | 47.5 | 47.0 | 60.0 | 55.0 | 77.3 | 64.0 | 52.5 | 47.5 |
UNaV, μEq/min | 0.23 | 0.15 | 0.67 | 0.36 | 0.50 | 0.63 | 0.59 | 1.19 | 1.03 | 0.82 | 0.22 | 0.37 | 0.60 | 0.96 | 1.17 | 0.96 | 0.67 | 0.71 |
Uosm, mOsm/kg H2O | 62 | 76 | 89 | 77 | 100 | 90 | 81 | 66 | 91 | 79 | 61 | 105 | 45 | 63 | 59 | 53 | 43 | 62 |
Cosm, μl/min | 11.1 | 16.9 | 26.6 | 18.5 | 32.5 | 25.1 | 14.0 | 10.5 | 21.0 | 13.0 | 11.0 | 18.5 | 9.5 | 12.2 | 17.0 | 13.0 | 8.5 | 11.0 |
CIn, μl/min | 725 | 723 | 710 | 735 | 705 | 725 | 533 | 581 | 541 | 547 | 532 | 541 | 1,365 | 1,455 | 1,440 | 1,403 | 1,369 | 1,490 |
RD2 | RD4 | RD6 | ||||||||||||||||
SNa, mEq/liter | 126 | 123 | 123 | 128 | 126 | 126 | 130 | 128 | 127 | |||||||||
V, μl/min | 70.0 | 60.0 | 98.3 | 69.0 | 73.5 | 52.5 | 47 | 52.5 | 66.0 | 57.3 | 55.5 | 50.0 | 42.5 | 52.5 | 58.3 | 56.6 | 50.0 | 55.0 |
UNaV, μEq/min | 0.41 | 0.67 | 0.85 | 0.59 | 0.47 | 0.50 | 0.48 | 0.79 | 1.09 | 0.69 | 0.47 | 0.71 | 0.16 | 0.26 | 0.30 | 0.28 | 0.25 | 0.28 |
Uosm, mOsm/kg H2O | 62 | 88 | 85 | 90 | 50 | 71 | 65 | 118 | 95 | 130 | 76 | 51 | 95 | 118 | 114 | 130 | 86 | 127 |
Cosm, μl/min | 17.0 | 20.5 | 32.0 | 23.3 | 13.2 | 14.0 | 11.0 | 23.0 | 24.5 | 29.0 | 15.5 | 9.5 | 14.5 | 23.0 | 25.0 | 27.0 | 16.2 | 26.5 |
CIn, μl/min | 1,230 | 1,320 | 1,231 | 1,172 | 1,458 | 1,265 | 882 | 940 | 924 | 908 | 920 | 922 | 583 | 625 | 608 | 594 | 537 | 584 |