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. Author manuscript; available in PMC: 2011 Oct 28.
Published in final edited form as: J Med Chem. 2010 Oct 28;53(20):7414–7427. doi: 10.1021/jm100884b

Table 4.

In vitro growth inhibitory effects of the ABI compounds in comparison to other anticancer drugs on multidrug-resistant melanoma cell line (MDR cell) and the matching sensitive parent cell line (Normal Melanoma cell).

Compound ID IC50 ± SEM (nM) (n=3)
MDA-MB-435 MDA-MB-435/LCC6MDR1 Resistance index*
5cb 24±2 30±4 1.3
4cb 38±3 30±2 0.8
4fb 50±6 35±3 0.7
Paclitaxel 4±1 277±41 69.3
Vinblastine 0.4±0.1 11±1 27.5
Colchicine 10±1 658±50 65.8
*

Resistance indexes were calculated by dividing IC50 values on multidrug-resistant cell line MDA-MB-435/LCC6MDR1 by IC50 values on the matching sensitive parental cell line MDA-MB-435.