Figure 7.

Expression of three familial PD-associated genes rescues mitochondrial fragmentation caused by αS. (A) Coexpression of PINK1, parkin or DJ-1 with αS rescues fragmentation of mitochondria, whereas their loss-of-function mutants do not. Cells were transfected as indicated and mitochondrial morphology was quantitated as in Figure 2B. (B) Single expression of PINK1, parkin or DJ-1 or each mutant alone does not affect mitochondrial morphology. Error bars indicate s.d. Expression controls are provided in Supplementary Figure S4. ***P⩽0.001.