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. 2010 Nov;2(11):a000547. doi: 10.1101/cshperspect.a000547

Figure 3.

Figure 3.

Posttranslational processing of the carboxyl terminus of prelamins A, B1, and B2. Processing takes place in a series of steps: (1) addition of a farnesyl group to the cysteine residue of the –CAAX box of pre-lamin A, prelamin B1 and prelamin B2 by a farnesyltransferase; (2) removal of the last three residues (−AAX) by an AAX endopeptidase; (3) methylation of the terminal carboxylic acid group (−COOH) by a carboxyl methyltransferase; (4) removal of the carboxyl terminal 15 amino acids of lamin A with the farnesyl attached by the metalloprotease Zmpste24/FACE1. This last proteolysis step does not occur on B-type lamins and therefore they remain farnesylated. Modified, with permission, from Dechat et al. (2008b).