Table 2.

Keio single-gene knockouts displaying hypersensitivity to bromoacetate

Genes are classified as follows: class 1, glutathione-mediated detoxification; class 2, general metabolism; class 3, membrane proteins and cell wall biosynthesis; class 4, DNA recombination and repair; class 5, transcriptional regulation; class 6, protein synthesis and degradation; and class 7, unassigned function. The sensitivity column indicates the degree of hypersensitivity of the indicated strain to bromoacetate as follows: no shading, moderate sensitivity; medium shading, severe sensitivity; and dark shading, very severe sensitivity.