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. 2010 Oct 4;107(42):18161–18166. doi: 10.1073/pnas.1005595107

Fig. 1.

Fig. 1.

Systematic identification of dysregulated miRNAs in WT and KO cerebella. (A) Venn diagram of the number of up- or down-regulated miRNAs detected in Mecp2-null cerebella. Note that a significant portion of aberrantly up-regulated mature miRNAs is detected consistently in Mecp2-null mice at both the pre-/early-symptomatic stage (6 wk postnatal) and the symptomatic stage (8 wk postnatal). (B) Heat map representation of 18 mature miRNAs that are dysregulated consistently in Mecp2-null mice at both the pre-/early-symptomatic stage (four pairs of 6-wk-postnatal WT and KO littermates sequenced as pooled samples) and the symptomatic stage (four pairs of >8-wk-postnatal WT and KO samples sequenced individually). Color intensity represents the degree of differential expression of miRNAs between WT and KO cerebella. (C) Genomic representation (NCBI build 36) of aggregated sequencing reads mapped to dysregulated miRNAs at the pre-/early-symptomatic (6-wk-postnatal) stage. Sequencing read counts for a given mature miRNA sequence are indicated also.