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. Author manuscript; available in PMC: 2010 Oct 26.
Published in final edited form as: Leukemia. 2009 Oct 1;23(12):2210–2221. doi: 10.1038/leu.2009.174

Table 5.

New proposed International Myeloma Working Group molecular cytogenetic classification

Percentage
of patients		 Clinical and laboratory features
Hyperdiploid 45 More favorable, IgG-κ, older
patients.
Non-hyperdiploid 40 Aggressive, IgA-λ, younger
individuals
Cyclin D
translocation		 18
 t(11;14)(q13;q32) 16 Upregulation of CCND1; favorable
prognosis; bone lesions. Two
subtypes by GEP
 t(6;14q)(p21;32) 2 Probably same as CCND1
 t(12;14)(p13;q32) <1 Rare
MMSET
translocation		 15
t(4;14)(p16;q32) 15 Upregulation of MMSET;
upregulation of FGFR3 in 75%
unfavorable prognosis with
conventional therapy; bone lesions
less frequent
MAF translocation 8 Aggressive
 t(14;16)(q32;q23) 5 Confirmed as aggressive by at
least two series
 t(14;20)(q32;q11) 2 One series shows more aggressive
disease.
 t(8;14)(q24;q32) 1 Unknown effect on outcome but
presumed aggressive.
Unclassified (other) 15 Various subtypes and some with
overlap