TABLE.

Blood Protein Binding of Cyclosporine

Subjects	WB/P	RBC/B	B/P	H	B/WB
Kidney Transplant
1	1.35	18.94	0.11	0.35	0.081
2	1.02	13.42	0.08	0.36	0.078
3	0.85	10.44	0.06	0.43	0.071
4	1.15	8.84	0.16	0.39	0.139
5	0.94	17.25	0.05	0.28	0.053
6	0.93	12.90	0.06	0.37	0.065
7	0.91	15.02	0.04	0.23	0.044
8	1.21	10.95	0.17	0.25	0.140
Mean ± SD	1.05 ± 0.17*	13.47 ± 3.46*	0.09 ± 0.05*	0.33 ± 0.07*	0.084 ± 0.036
Liver Transplant
1	1.59	29.15	0.10	0.31	0.063
2	1.36	29.60	0.08	0.24	0.059
3	1.27	24.04	0.08	0.31	0.063
4	1.29	24.04	0.08	0.31	0.062
5	1.12	23.55	0.06	0.28	0.054
Mean ± SD	1.33 ± 0.17*	26.08 ± 3.02*	0.08 ± 0.01”	0.29 ± 0.03*	0.060 ± 0.004*
Healthy Subjects
1	1.69	19.19	0.14	0.43	0.083
2	2.06	19.15	0.20	0.39	0.097
3	2.05	19.60	0.17	0.45	0.083
4	1.93	17.97	0.19	0.39	0.098
Mean ± SD	1.93 ± 0.17	18.98 ± 0.70	0.17 ± 0.03	0.41 ± 0.03	0.090 ± 0.01

^*Significantly different from healthy subjects (P < .05).

WB = cyclosporine concentration in whole blood; P = in plasma; RBC = in red blood cells; B = in buffer; H = in hematocrit.