Table 2.
Associations of SPT/Recurrence with Mitochondrial SNPs Remaining Significant after Multiple Comparison Adjustment
| SNP | Host gene/region * | SNP type** | Mitochondrial Position | Allelic change | Genotype Counts§ | Cox model | Number of times in Bootstrap Sample | |||
|---|---|---|---|---|---|---|---|---|---|---|
| SPT | No SPT | HR (95% CI) ¶ | P Value | q value | P<0.01 | |||||
| mitoA11813G | Mt-ND4 | sSNP | 11812 | A>G | 146/1 | 259/34 | 0.06 (0.01–0.44) | 1.24×10−6 | 1.98×10-5 | 98 |
| mitoG15929A | Mt-TT | Non-coding | 15928 | G>A | 143/4 | 252/39 | 0.20 (0.08–0.56) | 5.47×10−5 | 4.37×10−4 | 94 |
| mitoA14906G | Mt-CYB | sSNP | 14905 | A>G | 141/6 | 248/41 | 0.28 (0.12−0.63) | 1.95×10−4 | 1.04×10−3 | 83 |
| mitoT10464C | Mt-TR | Non-coding | 10463 | T>C | 140/7 | 253/39 | 0.34 (0.16–0.73) | 1.04×10−3 | 4.17×10−3 | 73 |
| mitoA11252G | Mt-ND4 | sSNP | 11251 | A>G | 132/14 | 230/60 | 0.47 (0.27–0.82) | 3.21×10−3 | 1.03×10−2 | 68 |
| mitoG3012A | Mt-RNR2 | Non-coding | 3010 | G>A | 101/46 | 237/56 | 1.73 (1.21–2.49) | 3.87×10−3 | 1.03×10−2 | 70 |
| mitoT14767C | Mt-CYB | Thr > Ile | 14766 | T>C | 60/87 | 166/127 | 1.60 (1.14–2.25) | 5.90×10−3 | 1.35×10−2 | 67 |
*
ND4, NADH dehydrogenase subunit 4; TT, tRNA threonine; CYB, Cytochrome b; TR, tRNA arginine; RNR2, 16s ribosomal RNA.
**
sSNP, synonymous SNP; nsSNP, nonsynonymous SNP.
§
Genotype counts: wild genotype/variant genotype
¶
Adjusted for age, gender, ethnicity, smoking status, tumor site, tumor stage, and treatment.