Table 1. Baseline characteristics.
| 20 mg/kg/day PM for 21 days (N = 21) | 15 mg/kg/day PM for 28 days (N = 21) | |
| Age (years) | 19.4 (12.3) | 17.7 (9.8) |
| 4–14 years | 10 (47.6%) | 8 (38.1%) |
| 15–60 years | 11 (52.4%) | 13 (61.9%) |
| Sex (male) | 16 (76.2%) | 19 (90.5%) |
| Nutritional status * | ||
| Severely underweight | 2 (9.5%) | 0 |
| Underweight | 10 (47.6%) | 13 (61.9%) |
| Normal | 9 (42.9%) | 8 (38.1%) |
| Weight | 36.5 (16.5) | 40.0 (16.8) |
| Temperature (°C) | 38.9 (0.6) | 39.0 (0.6) |
| Heart rate (beats/min) | 106.2 (13.2) | 105.4 (12.1) |
| Spleen size (cm) | 5.9 (3.3) | 5.5 (3.6) |
| Liver size (cm) | 2.9 (3.0) | 3.0 (2.0) |
| Systolic BP (mm Hg) | 100.7 (12.1) | 99.0 (12.6) |
| Diastolic BP (mm Hg) | 61.9 (9.7) | 59.8 (10.4) |
| Log scale parasite count, | ||
| 6+ | 4 (19.1%) | 1 (4.8%) |
| 5+ | 0 | 0 |
| 4+ | 1 (4.8%) | 2 (9.5%) |
| 3+ | 1 (4.8%) | 2 (9.5%) |
| 2+ | 1 (4.8%) | 4 (19.1%) |
| 1+ | 14 (66.7%) | 12 (57.1%) |
| Hemoglobin (g/dL) | 7.6 (1.4) | 7.7 (0.9) |
| White-cell count (×103/µL) | 3.1 (1.2) | 2.8 (0.9) |
| Platelets (×103/µL) | 311.6 (165.8) | 251.7 (89.5) |
| AST (U/L) | 18.8 (5.3) | 19.9 (5.2) |
| ALT (U/L) | 18.1 (4.5) | 18.8 (4.7) |
| Bilirubin (µmol/L) | 12.0 (5.8) | 14.0 (10.4) |
| BUN (mmol/L) | 9.7 (3.1) | 9.5 (3.8) |
| Creatinine (µmol/L) | 55.1 (15.8) | 64.4 (19.4) |
Data are mean (SD) or n (%).
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BP, blood pressure; BUN, blood urea nitrogen.
*Based on Weight for Height (WHO child growth standards) if age <6 years) and BMI for Age if age 6–19 years; defined as severely underweight if z-score<−3SD; underweight if −3SD≤z-score <−2SD; normal if −2SD≤z-score<+1SD; and BMI if age >19 years: defined as severely underweight if <16, underweight: 16.0–18.4, normal: 18.5–24.9.