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. Author manuscript; available in PMC: 2011 Nov 15.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2010 Nov 15;78(4):983–991. doi: 10.1016/j.ijrobp.2010.06.052

Table 2.

Sialogogues.

Gustatory and tactile sialogogues* Pharmacological sialogogues
Acid-tasting substances Anetholetrithione
 acidic (sugar-free) sweets Benzapyrone
 acidic or effervescent drinks (lemon juice, citric acid, buttermilk) Betanechol chloride
Carbachol
 citric acid crystals Cevimeline**
 cotton-wool gauze soaked in a citric acid and glycerine solution Folia Jaborandi and tinctura Jaborandi
Neostigmine, neostigmine bromide, pyridostigmine bromide, destigmine bromide
 lemon pastilles
 lemon slices Nicotinamide and nicotine acid
 vitamin C tablets Pilocarpine hydrochloride**, pilocarpine nitrate
Miscellaneous substances: Potassium iodide
 dried pieces of reed root (calami rhizome) Trithioparamethoxyphenylpropene
 sugar-free chewing gum
 sugar-free sweets
 vegetables or fruits
*

Not all substances are recommended in dentulous patients as acidic products may induce demineralization of dental hard tissues

**

Only these agents have been approved for relief of xerostomia in humans and have undergone substantial, controlled clinical testing