Schematic diagram of the nuclear envelope showing localizations and interactions of various proteins. Boxes highlight diseases caused by mutations in genes encoding the proteins indicated. RD: restrictive dermopathy, HGPS: Hutchinson-Gilford progeria syndrome, PHA: Pelger-Huet anaomaly, EDMD: Emery-Dreifuss muscular dystrophy, ADLD: Adult onset autosomal dominant leukodystrophy, BSS: Barraquer-Simons syndrome, LGMD: limb-girdle muscular dystrophy; DCM: dilated cardiomyopathy; CMT: Charcot-Marie-Tooth, FPLD: familial partial lipodystrophy, MADA / MADB: mandibuloacral dysplasia, WNR: Werner syndrome. For more specific disease nomenclature, see Table 1, Table 2 and Table 3.