Table 1.
Change in HIV RNA and CD4+ T-Lymphocyte Count
| AZT (N = 58) | IFN-α (N = 54)a | AZT+IFN-α (N = 54)a | P valueb | |
|---|---|---|---|---|
| Virologic | ||||
| Baseline log viral load (copies/mL) | 3.51 ± 0.09 | 3.57 ± 0.11 | 3.66 ± 0.11 | 0.56 |
| Time to last viral load visit (weeks) | 47.5 ± 0.5 | 44.9 ± 1.7 | 45.2 ± 1.3 | 0.20 |
| Difference in log HIV RNA (copies/mL) | −0.06 ± 0.06 | −0.35 ± 0.09 | −0.47 ± 0.12 | 0.01 |
| Standardized area under curve for log HIV RNA | −0.02 ± 0.01 | −0.27 ± 0.02 | −0.41 ± 0.02 | 0.0001 |
| % Baseline HIV RNA <50 (copies/mL) | 1.7% | 3.9% | 1.9% | 0.75 |
| % Last HIV RNA <50 (copies/mL) | 3.5% | 13.5% | 13.5% | 0.09 |
| Immunologic | ||||
| Baseline CD4 count | ||||
| Absolute | 744 ± 27 | 686 ± 23 | 790 ± 35 | 0.08 |
| Percentage | 37.3 ± 1.0 | 37.1 ± 1.3 | 38.1 ± 1.2 | 0.46 |
| Time to last CD4 count (weeks) | 47.3 ± 0.5 | 44.4 ± 1.5 | 45.6 ± 1.1 | 0.77 |
| Change in CD4 count | ||||
| Absolute | −40 ± 22 | −102 ± 24 | −97 ± 28 | 0.13 |
| Percentage | 0.6 ± 0.6 | −1.5 ± 1.0 | −1.1 ± 0.7 | 0.18 |
Values for continuous variables are expressed as mean ± standard error, and are expressed as percentages for binary variables.
a
N = 52 in viral load analysis.
b
P values for comparing continuous variables are derived by using the Kruskal–Wallis test and P values for comparing binary variables are derived by using the χ2-test; P values <0.05 represent a significant difference among the 3 groups.
Abbreviations: AZT, zidovudine; IFN-α, interferon-α.