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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Bioorg Med Chem. 2010 May 11;18(13):4661–4673. doi: 10.1016/j.bmc.2010.05.025

Scheme 6.

Scheme 6

Reagents and conditions: (i) TFA, CH2Cl2, 0 °C; (ii) 11, Pd(PPh3)4 (10 mol %), CuI (50 mol %), Et3N (2 eq), DMF / THF (1:2), rt; (iii) 13, THF, rt; (iv) NaOMe (cat), MeOH, 0 °C.