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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Bioorg Med Chem. 2010 May 11;18(13):4661–4673. doi: 10.1016/j.bmc.2010.05.025

Scheme 3.

Scheme 3

Reagents and conditions: (i) MsCl (3 eq), pyr, 0 °C; (ii) NaBz (3 eq), acetamide, 120 °C; (iii) CH3COBr (5 eq), EtOAc:MeOH (10:1), 70 °C; (iv) Zn, c HCl (2% by vol), MeOH, rt; (v) CAN (0.6 eq), I2 (0.6 eq), CH3CN, 35 °C.