Table 3.
Odds ratio and 95% confidence intervals of intestinal metaplasia/dysplasia for IL1B haplotypes by race
| Race |
||||||
|---|---|---|---|---|---|---|
| Haplotypes a | Caucasians | African Americans | ||||
| Normal/NAG/MAG | IM/DYS | OR b(95 CI) | Normal/NAG/MAG | IM/DYS | OR b (95 CI) | |
| IL1B (−511/−31/+3954), % | ||||||
| C-T-C | 44 | 50 | 1.0 (reference) | 34 | 40 | 1.7 (1.0–2.9) |
| C-T-T | 17 | 18 | 0.9 (0.3–2.7) | 6 | 3 | 0.6 (0.1–2.7) |
| C-C-C | 0 | 0 | NA | 8 | 8 | 1.0 (0.4–2.6) |
| T-C-C | 30 | 32 | 0.8 (0.3–2.1) | 41 | 30 | 1.0 (reference) |
| T-C-T | 0 | 0 | NA | 10 | 16 | 2.5 (1.1–5.5) |
| Others | 9 | 0 | NA | 1 | 3 | 5.9 (0.9–41.3) |
Abbreviations: OR: odds ratio; CI: Confidence interval; NAG: Non-atrophic gastritis, MAG: Multifocal atrophic gastritis; IM: Intestinal metaplasia.
a
The estimation maximization algorithm accounts for missing alleles when phasing ambiguous haplotypes.
b
ORs adjusted for sex, age, smoking, education, and cagA status.